Cryptosporidium parvum

A Microbial Biorealm page on the genus Cryptosporidium parvum

Classification

Higher order taxa

Eukaryota; Alveolata; Apicomplexa; Coccidia; Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium; Cryptosporidium parvum

Species

NCBI: Taxonomy

Cryptosporidium parvum

Description and significance

Describe the appearance, habitat, etc. of the organism, and why it is important enough to have its genome sequenced. Describe how and where it was isolated. Include a picture or two (with sources) if you can find them.

Genome structure

Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence? Does it have any plasmids? Are they important to the organism's lifestyle?

Cell structure and metabolism

Describe any interesting features and/or cell structures; how it gains energy; what important molecules it produces.

Ecology

Describe any interactions with other organisms (included eukaryotes), contributions to the environment, effect on environment, etc.

Pathology

How does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.

Application to Biotechnology

Does this organism produce any useful compounds or enzymes? What are they and how are they used?

Current Research

Enter summaries of the most recent research here--at least three required

References

Pain, A., Crossman, L., and Parkhill, J. “Comparative Apicomplexan genomics”. Nature Reviews Microbiology. 2005. Volume 3. p. 454-455. http://www.nature.com/nrmicro/journal/v3/n6/full/nrmicro1174_fs.html

Abrahamsen, M., Templeton, T., Enomoto, S., Abrahante, J., Zhu, G., Lancto, C., Deng, M., Liu, C., Widmer, G., Tzipori, S., Buck, G., Xu, P., Bankier, A., Dear, P., Konfortov, B., Spriggs, H., Lyer, L., Anantharaman, V., Aravind, L., and Kapur, V. “Complete Genome Sequence of the Apicomplexan, Cryptosporidium parvum”. Science. 2004. Volume 304. p. 441-445. http://www.sciencemag.org/cgi/content/full/304/5669/441

Rider, S., Cai, X., Sullivan, W., Smith, A., Radke, J., White, M., and Zhu, G. “The Protozoan Parasite Cryptosporidium parvum Possesses Two Functionally and Evolutionarily Divergent Replication Protein A Large Subunits”. J. Biol. Chem. 2005. Volume 280. p. 31460-31469. http://www.jbc.org/cgi/content/full/280/36/31460

Casadevall, A., Dadachova, E., Pirofski, L. “Passive Antibody Therapy for Infectious Diseases”. Nature Reviews Microbiology. 2004. Volume 2. p. 695-703 http://www.nature.com/nrmicro/journal/v2/n9/full/nrmicro974_fs.html

Pain, A., Crossman, L., Sebaihia, M., Cerdeño-Tárraga, A., and Parkhill, J. “Strength in Diversity”. Nature Reviews Microbiology. 2004. Volume 2. p. 358-359. http://www.nature.com/nrmicro/journal/v2/n5/full/nrmicro889_fs.html

Widmer, G., Yang, Y., Bonilla, R., Tanriverdi, S., and Ciociola, K. “Preferential infection of dividing cells by Cryptosporidium parvum”. Parasitology. 2006. Volume 133. p. 131-138. http://journals.cambridge.org/action/displayFulltext?type=6&fid=454979&jid=&volumeId=&issueId=02&aid=454977&fulltextType=RA&fileId=S0031182006000151

“Cryptosporidiosis Control and Prevention”. Center for Disease Control and Prevention. http://www.cdc.gov/ncidod/dpd/parasites/cryptosporidiosis/crypto_control_prevent.htm

Bandyopadhyay, K., Kella, K., Moura, I., Cristina, M., Carollo, C., Graczyk, T., Slemenda, S., ohnston, S., Silva, A. “A rapid microsphere assay for identification of Cryptosporidium hominis and Cryptosporidium parvum in stool and environmental samples”. 2007. Published online ahead of print. http://jcm.asm.org/cgi/reprint/JCM.00138-07v1?view=long&pmid=17652477

"Foodborne Pathogenic Microorganisms and Natural Toxins Handbook, Cryptosporidium parvum”. U.S. Food and Drug Administration. http://www.cfsan.fda.gov/~mow/chap24.html

Guisar R., Herrera, M., Bandala, E., Garcia, J., and Corona-Vasquez, B. “Inactivation of waterborne pathogens using solar photocatalysis”. Journal of Advanced Oxidation Technologies. 2007. Volume 10. p. 435-438. http://portal.isiknowledge.com/portal.cgi?DestApp=WOS&Func=Frame

Edited by student of Rachel Larsen Angela Wang