Rhinopneumonitis: Difference between revisions
| Line 16: | Line 16: | ||
==Cell structure, metabolism & life cycle== | ==Cell structure, metabolism & life cycle== | ||
Provide a physical and biochemical description of the organism. What kind of organism is it, what does it look like, how is it built, what are its metabolic properties, how can it be identified, what is it's life cycle, &c. In other words, describe the organism from <i>its</i> perspective. | Provide a physical and biochemical description of the organism. What kind of organism is it, what does it look like, how is it built, what are its metabolic properties, how can it be identified, what is it's life cycle, &c. In other words, describe the organism from <i>its</i> perspective. | ||
The viral DNA of rhinopneumonitis is enclosed in the central nucleocapsid, which is composed of 162 hollow capsomeres arranged as a shell. The nucleocapsid is surrounded by a flexible lipid membrane that contains virus-encoded glycoprotein. | |||
The life cycle of rhinopneumonitis is 1. infection, 2. establishment of latency, 3. periodic reactivation from latency, and 4. respiratory shedding with transmission to new hosts. | |||
The latent carrier state is essential the maintenance and spread of the the virus. Latency is a reversible state, so the virus can deactivate and reactivate when production deems fit. Transmission of the virus is efficient and outbreaks can spread rapidly in dense horse populations. | |||
==Ecology (including pathogenesis)== | ==Ecology (including pathogenesis)== | ||
Revision as of 19:04, 30 October 2011
A Microbial Biorealm page on the genus Rhinopneumonitis
Classification
Virus; Incertae sedis; Incertae sedis; Herpesvirales; Herpesviridae ; Varicellovirus; Equine Herpesvirus
Description and significance
Rhinopneumonitis, also called rhino, is an inflammation of the mucosa of the nasal cavities and lungs in horses. It is caused by the equine herpes virus and only affects horses. Almost all adult horses are infected due to natural exposure after birth. After infection, the virus hibernates in the lymph nodes of the respiratory system and the horse is infected for the rest of its life. Whether or not the horse exhibits symptoms of the disease depends on the strength of the immune system. The immune system keeps the virus in check and if it is busy with other diseases or problems affecting the horse, the virus can escape its confinement. Rhino is similar to the human herpes virus in this way because of its capability of latency and relapse. Symptoms of the repiratory disease caused by the virus include: fever, hacking cough, nasal discharge, enlarged lymph nodes in the neck, and stocking up and heat in the lower legs. Respiratory disease is the most common illness caused by the virus, but the virus can also cause abortion in brood mares. Vaccinations against herpes viruses are not very effective because the virus lives in the horse and affects its immune system. However, vaccinations are most important for brood mares to protect them against viral abortion. Minimal protection is vaccinating once a year. To prevent respiratory disease in young horses requires administration every 2-3 months and to prevent abortion, mares should be vaccinated three times during gestation.
Genome structure
The Rhinopneumonitis virus is composed of large, 150 kb, double-stranded DNA genomes that are enclosed within a protein capsid and surrounded by a delicate lipid envelope containing a dozen different glycoproteins. The virus's chromosome is circular. Because the envelope is so delicate, the survival of the virus in the environment is very limited and makes them highly susceptible to destruction by common disinfectants. EHV-1 and EHV-4 strains of rhino contain 76 homologous, co-linear genes.
Cell structure, metabolism & life cycle
Provide a physical and biochemical description of the organism. What kind of organism is it, what does it look like, how is it built, what are its metabolic properties, how can it be identified, what is it's life cycle, &c. In other words, describe the organism from its perspective.
The viral DNA of rhinopneumonitis is enclosed in the central nucleocapsid, which is composed of 162 hollow capsomeres arranged as a shell. The nucleocapsid is surrounded by a flexible lipid membrane that contains virus-encoded glycoprotein.
The life cycle of rhinopneumonitis is 1. infection, 2. establishment of latency, 3. periodic reactivation from latency, and 4. respiratory shedding with transmission to new hosts. The latent carrier state is essential the maintenance and spread of the the virus. Latency is a reversible state, so the virus can deactivate and reactivate when production deems fit. Transmission of the virus is efficient and outbreaks can spread rapidly in dense horse populations.
Ecology (including pathogenesis)
Describe its habitat, symbiosis, and contributions to environment. If it is a pathogen, how does this organism cause disease? Human, animal, plant hosts? Describe virulence factors and patient symptoms.
Interesting feature
Describe in detail one particularly interesting aspect of your organism or it's affect on humans or the environment.
References
http://www.petplace.com/horses/rhinopneumonitis/page1.aspx
Allen, G.P. "Respiratory Infections by Equine Herpesvirus Types 1 and 4". Equine Respiratory Diseases, P. Lekeux (Ed.) 2002. http://www.ivis.org/special_books/Lekeux/allen/IVIS.pdf
