Parkinson's

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Introduction

Parkinson’s Disease (PD) is a neurogenic disorder associated primarily with motor dysfunctions such as bradykinesia, awkward gait, and postural instability, and, more recently, with several psychological or neurological states. Major Depressive Disorder commonly presents as a comorbidity with PD, and cognitive dysfunctions, particularly in cortical areas pertaining to executive functions such as judgement and planning, are also frequent, and in need of further research. Fortunately, recent scientific investigations into these and other detrimental effects of PD have resulted in several discoveries that could set the foundations for novel treatments to increase quality of life for individuals afflicted by this progressive, incurable, degenerative illness.

This image, part of an article on Parkinson's Disease published by the Siberian Times in 2012, depicts several of the major, noticeable, motor-related deficits frequent in patients diagnosed with the disease. http://siberiantimes.com/science/casestudy/news/a-major-breakthrough-in-treating-parkinsons-disease-cannot-reach-patients/.


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Introduce the topic of your paper. State your health service question, and explain the biomedical issues.

Section 1

The term “punding” refers to purposeless, often repetitive behaviors such as lip smacking, hand shaking, or finger waggling. Contrary to common belief, punding, present in about 5.4% of patients diagnosed with PD, is most frequently a side effect of medications received for PD, and not of the disease itself. While punding itself may not cause critical medical problems, it is considered an indicator of later-stage PD, and, depending on level of severity, it may substantially decrease a patient’s quality of life.

Recently, a study published in July 2015 showed punding behaviors to relate positively to high levels of L-DOPA drug therapy, presentation of dyskinesia, and Impulse Control Disorder (ICD.) The study also assessed regions of cortical degeneration in PD patients, finding high levels of thinning in prefrontal brain regions. These results supported other findings that PD-diagnosed individuals are less effective in performing executive functions such as planning, or decision-making.

Section 2

Include some current research, with at least one figure showing data.

Section 3

Include some current research, with at least one figure showing data.

Conclusion



References

[1] Hodgkin, J. and Partridge, F.A. "Caenorhabditis elegans meets microsporidia: the nematode killers from Paris." 2008. PLoS Biology 6:2634-2637.



Authored for BIOL 291.00 Health Service and Biomedical Analysis, taught by Joan Slonczewski, 2016, Kenyon College.