Photorhabdus luminescens Toxins as Therapeutic Agents

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Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.


By [Oliver Kendall]

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Introduce the topic of your paper. What is your research question? What experiments have addressed your question? Applications for medicine and/or environment? Photorhabdus luminescens is a gram negative pathogenic bacteria that engages in a symbiotic relationship with nematodes. P. luminescens is the only known terrestrial bacteria that performs bioluminescent reactions. P. luminescens are a part of the photorhabdus genus of the Enterobacteriaceae family. There are three species of Photorhabdus,with two of them living in nematodes, and the third has been found in human wounds. P. luminescens is interesting as a microbe because it engages in symbiotic and pathogenic activities. In terms of symbiosis, P. luminescens lives in the gut of nematodes until the nematode infects a small insect like caterpillars. Once in the caterpillar, the nematode releases P. luminescens, where it releases a variety of toxins to kill the organism and provide nutrients for itself and for the nematode. These toxins are being looked at as potential therapeutic agents because of their efficacy as antimicrobial agents.
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Conclusion

References

  1. ↑ 1.0 1.1 Hodgkin, J. and Partridge, F.A. "Caenorhabditis elegans meets microsporidia: the nematode killers from Paris." 2008. PLoS Biology 6:2634-2637.
  2. ↑ Bartlett et al.: Oncolytic viruses as therapeutic cancer vaccines. Molecular Cancer 2013 12:103.



Authored for BIOL 238 Microbiology, taught by Joan Slonczewski, 2021, Kenyon College.

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