Norovirus

A Microbial Biorealm page on the genus Norovirus

Classification

Higher order taxa

Genus: Norovirus belonging to the Calciviridae family.

Domain; Phylum; Class; Order; family [Others may be used. Use NCBI link to find]

Species

NCBI: Taxonomy

Genus species

Description and significance

Describe the appearance, habitat, etc. of the organism, and why you think it is important.

Genome structure

Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence?

Virion Structure

Interesting features of cell structure; how it gains energy; what important molecules it produces.

Ecology

Habitat; symbiosis; contributions to the environment.

Pathology

How does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.

Current Research

Enter summarries of the most rescent research here--at least three required

References

Asanaka, M., Atmar, R.L., Ruvolo, V., Crawford, S.E., Frederick, H.N., and Estes, M.K. "Replication and packaging of Norwalk virus RNA in cultured mammalian cells". Proceedings of the National Academy of Sciences. 2005. Volume 10(29). p. 10327-10332.

Bertolotti-Ciarlet, A., White, L.J., Chen, R., Venkataram Prasad, B.V., and Estes, M.K. “Structural Requirements for the assembly of Norwalk virus-like particles”. Journal of Virology. 2002. Volume 76. p. 4044-4055.

Billgren, M., Chistenson, B., Hedlund, K.O., and Vinje, J. "Epidemiology of Norwalk-like Human Caliciviruses in Hospital Outbreaks of Acute Gastroenteritis in the Stockholm Area in 1996". Journal of Infection. 2002. Volume 44. p. 26-32. In: Asanaka, M., Atmar, R.L., Ruvolo, V., Crawford, S.E., Frederick, H.N., and Estes, M.K. "Replication and packaging of Norwalk virus RNA in cultured mammalian cells". Proceedings of the National Academy of Sciences. 2005. Volume 10(29). p. 10327-10332.

Chang, K., and George, D.W. “Interferons and ribavirin effectively inhibit Norwalk virus replication in replicon-bearing cells”. Journal of Virology. 2007. Volume 81(22). p. 12111-12118.

Clarke, I.N., and Lambden, P.R. “Organization and Expression of Calicivirus Genes”. The Journal of Infectious Diseases. 2000. Volume 181. p. S309-16.

Dolan, R. “Norovirus—challenges to control”. New England Journal of Medicine. 2007. Volume 357(11). p. 1072-1073.

Fankhauser, R.L., Noel, J.S., Monroe, S.S., Ando, T., and Glass, R.I. "Molecular Epidemiology of “Norwalk-like Viruses” in Outbreaks of Gastroenteritis in the United States". Journal of Infectious Diseases. 1998. Volume 178. p. 1571-1578. In: Asanaka, M., Atmar, R.L., Ruvolo, V., Crawford, S.E., Frederick, H.N., and Estes, M.K. "Replication and packaging of Norwalk virus RNA in cultured mammalian cells". Proceedings of the National Academy of Sciences. 2005. Volume 10(29). p. 10327-10332.

Harrington, P.R., Lindesmith, L., Yount, B., Moe, C.L., and Baric, R.S. “Binding of Norwalk virus-like particles to ABH histo-blood group antigens is blocked by antisera from infected human volunteers or experimentally vaccinated mice”. Journal of Virology. 2002. Volume 76(23). p. 12335-12343.

Lindesmith, L., Moe, C., Marionneau, S., Ruvoen, N., Jiang, X., Lindblad, L., Stewart, P., LePendu, J., and Baric, R. “Human susceptibility and resistance to Norwalk virus infection”. Nature Medicine. 2003. Volume 9(5). p. 548-553.

LoBue, A.D., Lindesmith, L., Yount, B., Harrington, P.R., Thompson, J.M., Johnston, R.E., Moe, C.L., and Baric, R.S. “Multivalent Norovirus vaccines induce strong mucosal and systemic blocking antibodies against multiple strains”. Vaccine. 2006. Volume 24. p. 5220-5234.

Prasad, B.V., Rothnagel, V.R., Jiang, X., and Estes, M.K. “Three-dimensional structure of baculovirus-expressed Norwalk virus capsids”. Journal of Virology. 1994. Volume 68. p. 5117-5125. In: Bertolotti-Ciarlet, A., White, L.J., Chen, R., Venkataram Prasad, B.V., and Estes, M.K. “Structural Requirements for the assembly of Norwalk virus-like particles”. Journal of Virology. 2002. Volume 76. p. 4044-4055.

Straub, T.M., Honer zu Bentrup, K., Orosz-Coghlan, P., Dohnalkova, A., Mayer, B.K., Bartholomew, R.A., Valdez, C.O., Bruckner-Lea, C.J., Gerba, C.P., Abbaszadegan, M., and Nickerson, C.A. “In vitro cell culture infectivity assay for human Noroviruses”. Emerging Infectious Diseases. 2007. Volume 13(3). p. 396-403.

Waters, A., Coughlan, S., and Hall, W.W. “Characterization of a novel recombination event in the Norovirus polymerase gene”. Virology. 2007. Volume 363. p. 11-14.

Widdowson, M.A., Monroe, S.S., and Glass, R.I. “Are Noroviruses emerging?”. Emerging Infectious Diseases. 2005. Volume 11(5). p. 735-737.

Zheng, D., Ando, T., Fankhauser, R.L., Beard, R.S., Glass, R.I., and Monroe, S.S. “Norovirus classification and proposed strain nomenclature”. Virology. 2006. Volume 346. p. 312-323.

Edited by student of Emily Lilly at University of Massachusetts Dartmouth.