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In a study done by Helene Malet, et.al, the binding of the NS5 RNA-dependent RNA polymerase (RdRp) was tested for possible antiviral drugs. The 5’ and 3’ terminal regions of the Flavivirus RNA genome form complementary cyclization sequences. This structure is important for RNA replication. The RdRp domain binds to the promoter stem loop A at the 5’ end (SLA) of the genome and initiates RNA synthesis using the 3’ end as a template. Figure was adapted from Filomatori et al. (2006).
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 18:51, 15 April 2009 | | 564 × 359 (46 KB) | Knightj (talk | contribs) | Figure was adapted from Filomatori et al. (2006). |
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