Zinc Finger Nuclease (ZFN)

Introduction

Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.

Zinc finger nucleases (ZFNs)are enzymes which can be used to cleave DNA at select points, makes them useful tools for genetic engineering. ZFNs are composed of a DNA binding-domain and a DNA cleaving-domain.

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Legend/credit: Diagram of a zinc finger nuclease. The zinc fingers are part of the binding-domain and have precisely identified and bound to a group of matching nucleobases in the DNA sequence. The cleaving-domains are Fok 1, which make a break in the DNA in both strands. Image credit to Stewart, C. N. and Burris, J. Jr.
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Subscript: H₂O
Superscript: Fe³⁺

Section 1

Include some current research in each topic, with at least one figure showing data.

Section 2

Include some current research in each topic, with at least one figure showing data.

Section 3

Include some current research in each topic, with at least one figure showing data.

Conclusion

Overall paper length should be 3,000 words, with at least 3 figures.

References

Porteus, M. H. and Carroll, D. "Gene targeting using zinc finger nucleases". Nature Biotechnology. 2005. Volume 23. p. 967-973.

Dana Carroll. "Genome engineering with zinc-finger nucleases". Genetics. 2011. Volume 188(4). p. 773–782.

"Genetic and Physical Analysis of Double-Strand Break Repair and Recombination in Saccharomyces Cerevisiae" Rudin,N., Sugarman, E., and Haber, J. E. Genetics. 1989. Volume 122(3). p. 519–534.