Chest Port Microbial Infections
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By [Hannah Lorico Hertz]
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A chest port is a catheter connected to a reservoir inserted under the skin of the chest and used to administer medicines directly into a vein over a long period of time. Chest ports are commonly used to administer long-term chemotherapy in children because of the ease of care for port maintenance. In comparison to an IV line, chest ports can stay in place for months at a time, can be used to collect blood samples without needles, and have a lower risk of infection over time.
Although port infections are not as common as other catheter infections, microbial infections are still the most significant complication resulting in port excision. About 5% of patients require port excision because of infection[1]. Infections of implanted devices most commonly result from Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Streptococcus vidrians, Klebsiella pneumonia, and Pseudomona aeruginosa. [2] Of the above microbes, S. epidermidis is the most relevant port associated pathogen. In the United States, Jukes et al. estimate 80% of nosocomial catheter related bloodstream infections (CRBSI) are a result of S. epidermidis [3] .
S. epidermidis is a natural member of the human skin floraCite error: Closing </ref> missing for <ref> tag
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References
- ↑ Funaki, Brian. “Subcutaneous Chest Port Infection.” Seminars in Interventional Radiology, 22.3 (2005): 245–247. PMC.
- ↑ Paredes, J.,Alonso-Acre, M., Schmidt, C., Valderas, D., Sedano, B., Legarda, J., Arizti, F., Gomez, E., Aguinaga, A., Del Pozo, J.L., Arana, S. "Smart central venous port for early detection of bacterial biofilm related infections" Biomed Microdevices, 16(2014): 365.
- ↑ Jukes, L., Mikhail, J., Bome-Mannathoko, N., Hadfield, S.J., Harris, L.G., El-Bouri, K., Davies, A.P., Mack, D. "Rapid differentiation of Staphylococcus aureus, Staphylococcus epidermidis and other coagulase-negative staphylococci and meticillin susceptibility testing directly from growth-positive blood cultures by multiplex real-time PCR" J. Med. Microbiol, 59 (2010):1456–1461
- ↑ Bartlett et al.: Oncolytic viruses as therapeutic cancer vaccines. Molecular Cancer 2013 12:103.
Authored for BIOL 238 Microbiology, taught by Joan Slonczewski, 2017, Kenyon College.
