Bacteroides fragilis

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Introduction

Bacteroides fragilis (BF) is a Gram-negative bacterium found in the human colon [1]. It is responsible for a large number of opportunistic infections in hospitals and contributes significantly to morbidity and mortality [2]. In addition to opportunistic infections, BF has been known to cause complications such as colorectal cancer and cholitis. [3] This bacterium is of interest to researchers because of its ability to evade immune responses and evolving drug resistance.

Colony of Bacteroides fragilis, Gram-stained and magnified 1000x. Image taken by Don Stalon. Source: Centers for Disease Control and Prevention

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Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.
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Section 1 Genetics

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Section 2 Microbiome

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Conclusion

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References

[1] Kuwahara, Tomomi, et al. "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation." Proceedings of the National Academy of Sciences 101.41 (2004): 14919-14924.

[2] Carolyn Redondo, Maria, et al. "Attributable mortality of bacteremia associated with the Bacteroides fragilis group." Clinical infectious diseases 20.6 (1995): 1492-1496.

[3] Sears, Cynthia L. "Enterotoxigenic Bacteroides fragilis: a rogue among symbiotes." Clinical microbiology reviews 22.2 (2009): 349-369.

Edited by James Cawthon, student of Joan Slonczewski for BIOL 116 Information in Living Systems, 2019, Kenyon College.