Faecalibacterium prausnitzii Relating to Gastroenterology Diseases
Introduction
By Kayla Arone
Faecalibacterium prausnitzii is a Gram-negative bacterium, non-sporeforming and extremely oxygen sensitive. This type of gut bacteria is the most abundant bacterium in the human gut, accounting for 5-15% of the total bacterial population in the gut. It is very prevalent in human populations as it is detected in 85% of gut samples and F. prausnitzii is considered to be very prevalent in the GI track of humans. Levels of F. prausnitzii differ by age and gender as well with lower levels in women than men. Levels of F. prausnitzii can be first detected around 6-7 months of age and the abundance rises at around 2-3 years old suggesting that there are different evolutionary stages of F. prausnitzii. Decreased F. prausnitzii levels are observed in various forms of different inflammatory bowel disease (IBD), Crohn’s disease (CD), ulcerative colitis (UC), and colorectal cancer (CRC).
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Legend/credit: Magnified 20,000X, this colorized scanning electron micrograph (SEM) depicts a grouping of methicillin resistant Staphylococcus aureus (MRSA) bacteria. Photo credit: CDC. Every image requires a link to the source.
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Crohn's Disease
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Link between Faecalibacterium prausnitzii and Crohn’s Disease
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===Implications for the Gut Homeostasis ===Abundance of Bacteria In Crohn's Patients
Mechanisms and Interactions
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Anti-inflammatory Properties
Impact On the Gut Barrier
Interactions With the Immune System
Research Findings and Future Research
Studies on Faecalibacterium prausnitzii in Crohn’s Patients
Clinical Trials and Theraputic Approaches
Conclusion
References
Authored for BIOL 238 Microbiology, taught by Joan Slonczewski,at Kenyon College,2024
