Naegleria fowleri
A Microbial Biorealm page on the genus Naegleria fowleri
Classification
Higher order taxa
Eukaryota, Percoloza, Heterolobosea, Schizopyrenida, Vahlkampfiidae, Naegleria, fowleri
Species
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NCBI: Taxonomy |
Naegleria fowleri
Description and significance
Describe the appearance, habitat, etc. of the organism, and why you think it is important.
Genome structure
Few studies have been done involving the genome of Naegleria fowleri, though some important information has been discovered. Although it is known that N. fowleri is polyploidy,the exact number of genome copies is unknown (E). Its genome size was orginally estimated at over 70.6 kbp, obtained by summing the 16.5kpb ribosomal DNA and its 54.1kpb mitochondrial DNA (A). Both the rDNA and mtDNA sizes were calculated by restriction endonuclease fragments. Further research has discovered a 104 kbp genome with 23 chromosomes (G). The rDNA is kept on extrachomosonal, circular plasmids called episomes ranging in size from 14kpb to 17kbp. As the entire genome is polyploidy, these eposomes are multicopy episomes up to 4000 copies. Species classification is done using either 5.8s rDNA or SSUrDNA (G)
Life Cycle
Cell structure and metabolism
Interesting features of cell structure; how it gains energy; what important molecules it produces.
Ecology
Naegleria fowleri are found world wide in warm freshwater, either naturally geothermic pools or warm bodies of water created by industry such as industrial cooling water (H). Although they ideally grow at 37oC, the temperature of their human hosts, below 27oC, N. fowleri are able to survive by encysting. The amoeba is able to grow in environments up to 45oC (D). Although it is found all across the globe, the only place where N. fowleri contaminates public drinking water is in South Australia (H)
Pathology
How does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.
