HIV Drug Resistance
From MicrobeWiki, the student-edited microbiology resource
Introduction
By Lillian Spetrino
HIV-1 Protease
Protease Inhibitors
Protease Inhibitor Resistance
Three-dimensional structure of HIV PR dimer depicting the primary and secondary mutations associated with resistance to protease inhibitors (Johnson et al., 2008). Mutated residues are represented with their Ca atoms and colored red and blue for major and minor mutations, respectively. Active site aspartates and darunavir bound to the active site are represented in sticks. The figure was generated using the structure of highly mutated patient derived HIV PR (Saskova et al., 2009).
