Yellow fever virus

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University of Oklahoma Study Abroad Microbiology in Arezzo, Italy[1]

Computer-generated image of Yellow fever virus based on electron microscopy. From: Rayur.com [2]

Etiology/Bacteriology

Taxonomy

ICTV Virus Classification

Baltimore Classification

Description

Yellow fever virus (YFV) was the first proven human-pathogenic virus in 1927(jvi); it is a Group IV positive-sense single stranded RNA virus due to its direct mRNA-like functions in a host cell (cdc). It belongs to the family Flaviviridae and genus Flavivirus. Yellow fever virus was the first classified in both of these taxonomies, hence the “flavi” Latin root for “yellow”. Arthropod vectors are the main source for the spread of Yellow fever virus (e.g. mosquitos) like many other viruses in the Flaviviridae family (e.g. Hepatitis). There is a great deal of symmetry involved in the near spherical structure of YFV, similar to the other Flavivirus (e.g. Dengue, West Nile). YFV was named for the disease it causes in humans, Yellow fever. Humans are a dead-end host, terminating the virus’s life cycle and consequently suffering from much harsh symptoms than its native host. Yellow Fever, as a disease, took notable attention beginning in Philadelphia in 1793, killing 9 percent of the population, again in 1878 along the Mississippi with a death toll of 20,000, and the last major outbreak in the United States occurred in New Orleans in 1905 with 452 deceased (pbs). The rapid decrease in outbreaks is attributed to the work of the US Army Medical Corps Yellow Fever Commission led by the Virginian physician Walter Reed during the Spanish-Cuban-American War. Reed used the work of Cuban scientist Carlos Finlay to prove the role of mosquitos, particularly Aedes aegypti, in transmitting the disease (what he believed at the time to be bacterial) and thus was able to develop sanitation techniques in reducing the mosquito population (yellow fever). Infected individuals are characterized by general flu-like symptoms that in 15% of cases develop into the more toxic phase; the disease accounts for 200,000 incidents with 30,000 deaths a year (who).

Pathogenesis

Transmission/Reservoirs

Yellow fever virus (YFV) is transmitted via the mosquito vectors, Aedes and Haemagogus sps, and is endemic in many primate communities. However, humans are a dead-end host for the virus and fail to allow it to complete its life cycle. YFV transmission follows three distinct cycles: sylvatic (jungle) involving mosquitos transmitting virus through monkey intermediates to other mosquitos with the occasional human infection, intermidate (savannah) involve humans and monkeys surviving as intermediates with minor outbreaks occurring, and urban cycles, the largest of epidemics where infected humans introduce the virus to new mosquito population and non-immune people (who).

Incubation/Colonization

Yellow fever virus enters through the bite of a mosquito where it can remain dormant for 6 to 8 days causing massive viremia or quickly infects host cells, including dendritic cells of the lymph nodes and begin the acute stages of disease (cdc). The virus enters its host via receptor-mediated endocytosis and then utilizing its mRNA-like structure begins protein synthesis in the host’s endoplasmic reticulum so that it can begin viral replication in the cytoplasm (emed).

Epidemiology

Yellow fever virus is endemic among primate communities in sub-Saharan Africa and South America with intermittent epidemics in the countries around those areas(cdc). This includes a total of forty-four endemic countries, with a combined population of nearly one billion. With 90% of infection occurring in Africa, it has been estimated that in 2013 120,000 cases and 45,000 deaths occurred in Africa alone(who). Over time acquired immunity can occur which leads to an increased risk of contracting the disease among infants and children (cdc).

Virulence Factors

Yellow fever virus’s surface macromolecules are its main virulence factors and contribute to the entry, signaling and cell-cell interactions of the virus. The flavivirus E protein has many functions, but its role in binding and, fusion and cell entry is most important (advance).

Clinical Features

Yellow fever virus (YFV) is distinct from other viral hemorrhagic fevers by the severe injury to the liver causing the namesake jaundice appearance in victims (advance).Besides the liver complications. YFV is very similar to other viral infections, beginning with very minor flu-like symptoms early on that can progress to severe a more toxic stage. The toxic stage occurs in 15% of victims involving the jaundice described above, as well as deterioration of kidney function and internal bleeding (who).

Diagnosis

Treatment

Prevention

Risk Factors

Host Immune Response

References