Drug Resistance in Mycobacterium Tuberculosis

Figure 1. Activity Confirmation and Target Identification for N-(2-(4-methoxyphenoxy) ethyl)-3,5-dinitrobenzamide (DNB1) (A) Chemical structure of DNB1 (B) Results of intracellular assay from DNB1 of the benzamide scaffold (C) Inhibition of the in vitro growth fluorescence assays by DNB1 (D) Images of human macrophages infected with M. tuberculosis containing GFP after exposure to DNB1 and INH (5 µM) and DMSO for 7 days. NI: non infected (E) Dose-response curve for DNB1 on mouse macrophages infected with M. tuberculosis containing GFP and human macrophages after 5 days for 2 independent experiments (F) Gel showing the effect of DNB1 on the synthesis of decaprenyl-phospho-arabinose (DPA) by cell-free extracts of Mycobacterium smegmatis. Source: Christophe et al., 2009 [2

Figure 4. Principal correspondence analysis of UniFrac distances. Difference in gut microbiota according to (A) geographic location, (B) BMI, (C) Gender. Source: Ecobar et al., 2014[6