Quorum Sensing in Staphylococcus aureus Infections

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Introduction to Staphylococcus aureus

Scanning electron micrograph of Staphylococcus aureus biofilm. Micrograph taken by in Center for Biofilm Engineering CDC.

By Elizabeth Eder

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Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.
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Introduce the topic of your paper. State your health service question, and explain the biomedical issues.

Medical Relevance and MRSA

Include some current research, with at least one figure showing data.

Quorum Sensing System

Include some current research, with at least one figure showing data.

QS and Pathogenicity

Include some current research, with at least one figure showing data.

References

[1] Boucher, HW and Corey, GR (2008) Epidemiology of methicillin-resistant Staphylococcus aureus. Clinical Infectious Diseases 46:344-349.
[2] Haddadin, AS, Fappiano, SA, Lipsett, PA (2002) Methicillin resistant Staphylococcus aureus (MRSA) in the intensive care unit. Postgrad Med J 78:385-392.
[3] Novick, RP and Geisinger, E (2008) Quorum sensing in Staphylococci. Annu Rev Genet 42:541-564.
[4] Yarwood, JM, Bartels, DJ, Volper, EM, Greenberg, EP (2004) Quorum sensing in Staphylococcus aureus biofilms. J Bacteriol 186:1838-1850.
[5] Periasamy, S, Joo, H, Duong, AC, Bach, TL, Tan, VY, Chatterjee, SS, Cheung, GY, Otto, M (2011) How Staphylococcus aureus biofilms develop their characteristic structure. PNAS 109:1281-1286.
[6] Rutherford, ST and Bassler, BL (2012) Bacterial quorum sensing: its role in virulence and possibilities for its control. Cold Spring Harb Perspect Med 2:a012427.
[7] Yarwood, JM, Schlievert, PM (2003) Quorum sensing in Staphylococcus infections. J. Clin. Invest. 112:1620-1625.
[8] Klein, E, Smith, DL, Laxminarayan, R (2007) Hospitalizations and deaths caused by methicillin-resistant Staphylococcus aureus, United States, 1999–2005. Emerg Infect Dis 13(12):1840-1846.

Authored for BIOL 291.00 Health Service and Biomedical Analysis, taught by Joan Slonczewski, 2016, Kenyon College.