Lemierre's Syndrome

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Figure 1. A labeled image of a peritonsillar lesion that occurs during postanginal sepsis. Peritonsillar lesions are the most common deep neck infection. Image obtained through [ https://pedclerk.bsd.uchicago.edu/page/peritonsillar-abscess/University of Chicago].

Figure 2. The gram negative, anaerobic Fusobacterium necrophorum exhibiting bacilli morphology in a photomicrograph after being cultured for 48 hours in thioglycollate medium. Credit to CDC/ Dr. V. R. Dowell, Jr. in 1972. Image obtained from CDC Public Health Image Library.

By Jessie Griffith

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Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.
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Figure 3. Possible outcomes of infection with Fusobacterium necrophorum. The bacteria can cause a wide range of problems within the host, and this flowchart demonstrates the necessary intermediate steps to pass from one condition to another. Credit to Terry Riordan, 2007. Image obtained from Clin Microbiol Rev.

Figure 4. This scan of the neck is a computer generated tomography. It shows the thrombosis of the right external jugular vein. Credit to Lu in 2009 from the Journal of the American Board of Family Medicine. [ http://www.jabfm.org/content/22/1/79/F1.expansion.html/ Journal of the American Board of Family Medicine].

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Figure 5. The most recent data post 1970 on case studies reported on in literature, some of which involve Fusobacterium necrophorum others of which do not. Compiled and created by T. Riordan (2007) obtained from [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2176048/figure/f3/ National Institutes of health.

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Similarly, exposure to the exogenous Fusobacterium necrophorum, which is not a part of normal throat flora does not always result in Lemierre’s syndrome; it can also result in tonsillitis, meningitis, and metastatic lesions, and a whole host of other issues (Fig. 2)


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Authored for BIOL 238 Microbiology, taught by Joan Slonczewski, 2016, Kenyon College.