Gas gangrene (Clostridial myonecrosis)

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47 year-old-man with gas gangrene in the right leg. Picture was taken before hemipelvectomy. Large necrotic blisters of CO₂ caused by Clostridium are visible [1].

By Yiyi Ma

Structure of alpha-toxin. Two separate domains are pictured with N- and C-domains and Zn2+ and possible Ca2+ ions. [2].

Mechanism of pore formation by PFO on eukaryotic lipid bilayer. Association between lipid bilayer and PFO is greatest on edges of the membrane, where cholesterol is most accessible. [3].

The structure of PFO. β-barrels are evident in the four separate domains. Domain 1 and 2 are purple, domain 3 is green and domain 4 is red. [4].

Alpha-toxin shown interacting with lipid bilayer of eukaryotic membrane. Interactions with ions are shown, denoting the critical role of Ca2+ and Zn2+ in the function of alpha-toxin. [5].

Use of hyperbaric oxygen therapy in wound healing of 53-year-old diabetic patient with spontaneous gas gangrene. Leg was preserved with use of hyperbaric oxygen. Healthy tissue growth can be seen last image. [ttp://www.ijps.org/article.asp?issn=0970-0358;year=2012;volume=45;issue=2;spage=316;epage=324;aulast=Bhutani].

By Yiyi Ma

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Authored for BIOL 238 Microbiology, taught by Joan Slonczewski, 2017, Kenyon College.