Junin virus
1. Introduction
1.1. Classification of Junin Virus
- Superkingdom
- Viruses
- Domain
- Riboviria
- Kingdom
- Orthonavirae
- Phylum
- Negarnviricota
- Subphylum
- Polyploviricotina
- Class
- Ellioviricetes
- Order
- Bunyavirales
- Genus
- Arenaviridae
- Species
- Mammarenavirus
- Common Names
- Argentine Mammarenavirus, Junin Virus, Junin Arenavirus, JUNV
2. Description and significance
Describe the appearance, habitat, etc. of the organism, and why you think it is important.
- Include as many headings as are relevant to your microbe. Consider using the headings below, as they will allow readers to quickly locate specific information of major interest*
3. Genome structure
Junin Virus has a negative-sense double-stranded RNA genome that is made up of two segments: the large (L), which is 7.3 kbp, and the small (S), which is 3.5 kbp[6]. The two segments are configured in an ambisense orientation, which means the information on each strand is read in the opposite direction from the other[6]. The genome of the Junin Virus codes for four proteins. The L segment encodes a viral RNA polymerase called L polymerase, as well as a small zinc-binding protein called RING finger protein Z[6]. The S segment encodes the glycoprotein precursor (GPC) and the nucleoprotein (NP)[6]. The NP protein is the first protein that is translated. After translation of GPC, the protein is cleaved into two new glycoproteins: GP1 and GP2. GP1 is inserted in the peripheral membrane of the viral envelope, and GP2 becomes part of the integral membrane[7]. These proteins in the bilayer are involved in recognition and the entry of the virus into target cells. The cleaving of GPC also yields a signal stable peptide (SSP), which ensures that GPC responds properly to acidic conditions[6].
4. Cell structure
Interesting features of cell structure. Can be combined with “metabolic processes”
5. Metabolic processes
Describe important sources of energy, electrons, and carbon (i.e. trophy) for the organism/organisms you are focusing on, as well as important molecules it/they synthesize(s).
6. Ecology
Habitat; symbiosis; contributions to the environment.
7. Pathology
How does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.
8. Current Research
Include information about how this microbe (or related microbes) are currently being studied and for what purpose
9. References
It is required that you add at least five primary research articles (in same format as the sample reference below) that corresponds to the info that you added to this page. [Sample reference] Faller, A., and Schleifer, K. "Modified Oxidase and Benzidine Tests for Separation of Staphylococci from Micrococci". Journal of Clinical Microbiology. 1981. Volume 13. p. 1031-1035.
