Feline panleukopenia virus
Classification
Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Quintoviricetes; Piccovirales; Parvoviridae; Parvovirinae; Protoparvovirus; Protoparvovirus carnivoran 1
Species
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NCBI: [1] |
Genus species
Description and Significance
Describe the appearance, habitat, etc. of the organism, and why you think it is important.
FPV is a serious and potentially fatal issue among unvaccinated felines.
Genome Structure
Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence?
The genome of feline panleukopenia virus is a non-enveloped, single-stranded DNA virus with approximately 5123 nucleotides and 2 open-reading frames. The amount of base pairs in the DNA sequence varies depending on the specific strain of the virus. Due to the Y-type structure at the 3-terminal and the U-shaped structure at the 5-terminal, it is challenging for researchers to amplify the full-length genome of this virus and many others in the parvovirus genus.
Cell Structure, Metabolism and Life Cycle
Interesting features of cell structure; how it gains energy; what important molecules it produces.
Ecology and Pathogenesis
Habitat; symbiosis; biogeochemical significance; contributions to environment.
If relevant, how does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.
The virus can be transmitted either by the fecal-oral route or by indirect transmission via fomites contaminated by infected individuals. Using transferrin receptors FPV can enter cells and replicate inside of cells that are currently in the synthesis phase of mitosis. FPV can occur in cats younger than 1 year old, or unvaccinated or improperly vaccinated cats of any age. Severity of the virus depends on age, immunity of the individual and infections from other bacteria or viruses. FPV causes feline infections enteritis (FIE) which is a severe infection of the gut that is fatal and highly contagious. Clinical symptoms of infected individuals are lethargy, diarrhea, inappetence, fever, vomiting, weight loss. If left untreated or if the virus has progressed too far then death can occur usually because of dehydration, low blood sugar, imbalanced electrolytes, hemorrhaging, bacteria in the bloodstream or
References
Author
Page authored by Phoebe Chambers, student of Prof. Bradley Tolar at UNC Wilmington.
