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DRAFT

Introduction

Dengue is a term for a group of illnesses caused by four viruses, which are extremely relevant because they can infect humans. (Dengue) The viruses are known as DENV 1, DENV 2, DENV 3, and DENV 4. The primary vector of transmission is one of two types of mosquitos, Aedes aegypti and Aedes albopictus. Although the viruses developed in humans between 100 and 800 years ago, dengue was not a prominent illness until recently. (CDC epidemiology)


Dengue can manifest in two forms: dengue fever and dengue hemorrhagic fever (DHF). Currently, there is no medicine to target either type of infection. (CDC FAQ) It is important to know the symptoms symptoms of dengue infection and educate oneself about the illness. In order to design a treatment for dengue infection, it is important to understand the mechanism of infection and the structure of the dengue virus family.

Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.

At right is a sample image insertion. It works for any image uploaded anywhere to MicrobeWiki. The insertion code consists of:
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Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.
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Envelope Proteins

Envelope proteins (E proteins) allow the dengue viruses to interact with host cells. They are a type of glycoprotein on the exterior of the virus.

Structural Variation

The four different types of dengue virus have slightly different genomes, which means that they may have different protein structures. Antibodies that neutralize one type of dengue virus may be ineffective against another dengue strain due to these structural differences so understanding structural differences is key to treating the virus. Crystallography can show the folded structure of the proteins and allow for comparison of proteins from the different strains.

Section 2

Include some current research in each topic, with at least one figure showing data.

Section 3

Include some current research in each topic, with at least one figure showing data.

Conclusion

Overall paper length should be 3,000 words, with at least 3 figures.

References

Cited in text

Photo credits

Link Credits

[Sample reference] Takai, K., Sugai, A., Itoh, T., and Horikoshi, K. "Palaeococcus ferrophilus gen. nov., sp. nov., a barophilic, hyperthermophilic archaeon from a deep-sea hydrothermal vent chimney". International Journal of Systematic and Evolutionary Microbiology. 2000. Volume 50. p. 489-500.

Edited by (your name here), a student of Nora Sullivan in BIOL187S (Microbial Life) in The Keck Science Department of the Claremont Colleges Spring 2013.