Akkermansia muciniphila: Difference between revisions
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[] [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333879/ Caputo, Aurélia et al. “Whole-genome assembly of Akkermansia muciniphila sequenced directly from human stool.” Biology direct vol. 10 5. 19 Feb. 2015, doi:10.1186/s13062-015-0041-1] | [] [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333879/ Caputo, Aurélia et al. “Whole-genome assembly of Akkermansia muciniphila sequenced directly from human stool.” Biology direct vol. 10 5. 19 Feb. 2015, doi:10.1186/s13062-015-0041-1] | ||
[] [https://www.frontiersin.org/articles/10.3389/fmicb.2011.00166/full Derrien M., Van Baarlen P., Hooiveld G., Norin E., Muller M., De Vos W. M. (2011). Modulation of mucosal immune response, tolerance, and proliferation in mice colonized by the mucin-degrader Akkermansia muciniphila. Front. Microbiol. 2:166. 10.3389/fmicb.2011.00166] | |||
[] [https://www-sciencedirect-com.proxyiub.uits.iu.edu/science/article/pii/S0882401015301789 Derrien, Muriel, et al. “Akkermansia Muciniphila and Its Role in Regulating Host Functions.” Microbial Pathogenesis, vol. 106, 2017, pp. 171–181., doi:10.1016/j.micpath.2016.02.005.] | [] [https://www-sciencedirect-com.proxyiub.uits.iu.edu/science/article/pii/S0882401015301789 Derrien, Muriel, et al. “Akkermansia Muciniphila and Its Role in Regulating Host Functions.” Microbial Pathogenesis, vol. 106, 2017, pp. 171–181., doi:10.1016/j.micpath.2016.02.005.] |
Revision as of 22:42, 28 April 2020
Classification
Domain: Bacteria
Phylum: Verrucomicrobia
Class: Verrucomicrobiae
Order: Verrucomicrobiales
Family: Akkermansiaceae [Others may be used. Use NCBI link to find]
Species
NCBI: Taxonomy |
Akkermansia muciniphila
Description and Significance
Describe the appearance, habitat, etc. of the organism, and why you think it is important.
Akkermansia muciniphila is an anaerobic, Gram-negative, non-motile, non-spore-forming, oval-shaped bacterium.[] It is present in the human intestinal tract in high quantities, ranging from 39% to 84% of the total bacterial population. A.muciniphila is associated with the protective mucus lining of the intestines. Its presence in the mucus layer of the intestinal tract is particularly important because A.muciniphila is able to degrade host mucin into short chain fatty acids, or other products, to regulate the biological functions of the host.[] The high content of Akkermansia muciniphila is thought to play a major role in the health of the intestinal mucos, as well as regulate host immune responses and lipid metabolism. []
Genome Structure
Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence?
The complete genome of Akkermansia muciniphila has one circular chromosome of 2,664,102 bp with a G+C content of 55.8%.Akkermansia muciniphila has a total of 2,176 protein coding sequences and an overall coding capacity of 88.8%.[]
Cell Structure, Metabolism and Life Cycle
Interesting features of cell structure; how it gains energy; what important molecules it produces.
Ecology and Pathogenesis
Habitat; symbiosis; biogeochemical significance; contributions to environment.
If relevant, how does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.
References
Author
Page authored by Emma Schuster, student of Prof. Jay Lennon at IndianaUniversity.