Arcanobacterium haemolyticum

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Classification

Bacteria; Actinobacteria; Actinomycetia; Actinomycetales; Actinomycetaceae

Species

NCBI: [1]

Arcanobacterium haemolyticum

Description and Significance

Arcanobacterium haemolyticum is an important human and animal pathogen that is gram-positive and a facultative anaerobe (Vu & Rajnik, 2022). It appears to be a branching bacillus bacteria (Vu & Rajnik, 2022). From swabs and cultures done from swabs, it seems that even in healthy individuals (both human and animal) Arcanobacterium haemolyticum can be found on the skin and pharynx normally (Vu & Rajnik, 2022). As an obligate parasite, Arcanobacterium haemolyticum has been known to cause pharyngitis and skin lesions on some individuals, particularly adolescents and elderly patients (Vu & Rajnik, 2022), which makes it an important microbe to understand.

Genome Structure

The genome of strain 110108T, which is the type strain of Arcanobacterium haemolyticum, is a circular chromosome that is 1,986,154 bp long. 87.2% of the genome is DNA coding (1,744,192 bp), and the GC content of the genome is 53.13% (1,055,308 bp). The genome of Arcanobacterium haemolyticum codes for a total of 1,885 genes, with 64 of those being RNA genes and the other 1,821 genes being protein encoding genes (Yasawong et al., 2010).

Cell Structure, Metabolism and Life Cycle

Interesting features of cell structure; how it gains energy; what important molecules it produces.

Ecology and Pathogenesis

Habitat; symbiosis; biogeochemical significance; contributions to environment.

If relevant, how does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.

References

[Sample reference] Takai, K., Sugai, A., Itoh, T., and Horikoshi, K. "Palaeococcus ferrophilus gen. nov., sp. nov., a barophilic, hyperthermophilic archaeon from a deep-sea hydrothermal vent chimney". International Journal of Systematic and Evolutionary Microbiology. 2000. Volume 50. p. 489-500.

Yasawong, M., Teshima, H., Lapidus, A., Nolan, M., Lucas, S., Glavina Del Rio, T., Tice, H., Cheng, J. F., Bruce, D., Detter, C., Tapia, R., Han, C., Goodwin, L., Pitluck, S., Liolios, K., Ivanova, N., Mavromatis, K., Mikhailova, N., Pati, A., Chen, A., … Klenk, H. P. (2010). Complete genome sequence of Arcanobacterium haemolyticum type strain (11018). Standards in genomic sciences, 3(2), 126–135. https://doi.org/10.4056/sigs.1123072

Vu MLD, Rajnik M. Arcanobacterium Haemolyticum. [Updated 2022 Jul 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560927/

Author

Page authored by Madison Sadler, student of Prof. Bradley Tolar at UNC Wilmington.