Bacillus Calmette-Guérin therapy: Difference between revisions
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BCG vs chemo.jpg<br> | [[Image:BCG vs chemo.jpg|thumb|300px|right|Comparison of different BCG strains and chemotherapy with respect to recurrence. The majority of studies in this meta-analysis by [http://www.sciencedirect.com/science/article/pii/S0022534717392467 Boehm et al. in 2017] showed that their respective strains of BCG significantly reduced bladder cancer recurrence compared to chemotherapy.]] | ||
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Revision as of 01:29, 25 April 2017
Section
By [Karina Kunka]
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Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.
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Recent studies have found that the Pak1-dependent pathway activated by oncogenes is actually responsible for uptake of BCG via macropinocytosis.
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Efficacy
Mechanism of Action
Conclusion
References
- ↑ Redelman-Sidi et al., "Oncogenic Activation of Pak1-Dependent Pathway of Macropinocytosis Determines BCG Entry into Bladder Cancer Cells." 2013. Cancer Research 73:3 1156-1167.
- ↑ Hodgkin, J. and Partridge, F.A. "Caenorhabditis elegans meets microsporidia: the nematode killers from Paris." 2008. PLoS Biology 6:2634-2637.
- ↑ Bartlett et al.: Oncolytic viruses as therapeutic cancer vaccines. Molecular Cancer 2013 12:103.
Authored for BIOL 238 Microbiology, taught by Joan Slonczewski, 2017, Kenyon College.