Bacillus Calmette-Guérin therapy: Difference between revisions

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==Section 4==
==Mechanism of Action==
[[Image:BCG_therapy_Test.jpeg|thumb|300px|right|Suggested mechanism of action of BCG therapy as determined by [http://www.nature.com/nrurol/journal/v11/n3/full/nrurol.2014.15.html Redelman-Sidi et al. in 2014], showing uptake of BCG by bladder cancer cells to cytotoxicity and immune response.]]
[[Image:BCG_therapy_Test.jpeg|thumb|300px|right|Suggested mechanism of action of BCG therapy as determined by [http://www.nature.com/nrurol/journal/v11/n3/full/nrurol.2014.15.html Redelman-Sidi et al. in 2014], showing uptake of BCG by bladder cancer cells to cytotoxicity and immune response.]]



Revision as of 01:15, 25 April 2017

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Section

Fluorescence microscopy of bladder cancer cells (blue and red) infected with BCG (green). This 2013 study by Redelman-Sidifound et al. found that the some cancer-causing mutations also make the cancer cells susceptible to BCG therapy.


By [Karina Kunka]

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Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.
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Recent studies have found that the Pak1-dependent pathway activated by oncogenes is actually responsible for uptake of BCG via macropinocytosis. [1] [2] [3]

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Mechanism of Action

Suggested mechanism of action of BCG therapy as determined by Redelman-Sidi et al. in 2014, showing uptake of BCG by bladder cancer cells to cytotoxicity and immune response.

Conclusion

References



Authored for BIOL 238 Microbiology, taught by Joan Slonczewski, 2017, Kenyon College.