Whooping Cough
Symptoms
Pathogenesis
This cartoon represents the crystal structure for the Bordetella pertussis toxin protein complex. It was created by Takuma-sa from the work of Penelopy E Stein, Amechand Boohoo, Glen D Armstrong, Stephen A Cockle, Michel H Klein, and Randy J Read.
Current Vaccine Options
DwP Vaccine
DaP Vaccine
Recent Vaccine Failures
Incidents
Differences in Vaccine Efficacy
Other Hypotheses for the Failures
The Search for Improvement
References
"Pertussis Vaccines: WHO Position Paper." Weekly Epidemiological Record 85.40 (2010): 385-400. Academic Search Premier. Web. 26 Feb. 2015.
Clark, Thomas A. "Changing Pertussis Epidemiology: Everything Old is New Again." The Journal of Infectious Diseases 209.7 (2014): 978-981. Web. 26 Feb. 2015.
Klein, Nicola P., Joan Bartlett, Bruce Fireman, Ali Rowhani-Rahbar, and Roger Baxter. "Comparative Effectiveness of Acellular Versus Whole-Cell Pertussis Vaccines in Teenagers." Pediatrics. 131.6 (2013): 1716-1722. Web. 26 Feb. 2015.
Riolo, Maria A., Aaron A. King, and Pejman Rohani. "Can vaccine legacy explain the British pertussis resurgence?" Vaccine. 31(2013): 5903-5908. Web. 26 Feb. 2015.
Robbins, John B., Rachel Schneerson, Joanna Kubler-Kielb, Jerry M. Keith, Birger Trollfors, Evgeny Vinogradov, and Joseph Shiloach. "Toward a new vaccine for pertussis." PNAS. 111.9 (2014): 3213-3216. Web. 26 Feb. 2015.
