Borrelia burgdorferi and Lyme Disease Pathogenesis: Difference between revisions

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[[Image:Spirochete_Morphology.jpeg|thumb|300px|right| Diagram of spirochete showing the flagella and the flagellar motor in between the outer and inner membrane. [http://www.sciencedirect.com/science/article/pii/S1369527415001368]]
[[Image:Spirochete_Morphology.jpeg|thumb|300px|right| Diagram of spirochete showing the flagella and the flagellar motor in between the outer and inner membrane. [http://www.sciencedirect.com/science/article/pii/S1369527415001368]]
[[Image:Lyme Cycle.jpeg|thumb|300px|right| Diagram of B. burgendorferi life cycle and transmission from tick host to other organisms. [http://www.nature.com/nrmicro/journal/v10/n2/fig_tab/nrmicro2714_F1.html]]


Research Question: Why is the bacterium so good at evading the host's immune response? <ref>[http://www.jbc.org/content/early/2012/04/12/jbc.M112.344903.full.pdf+htm]=Troxell, Bryan, Haijun Xu, and Frank Yang. "Borrelia Burgdorferi, a Pathogen That Lacks Iron, Encodes a Manganese-dependent Superoxide Dismutase Essential for Resistance to Streptonigrin." Borrelia Burgdorferi, a Pathogen That Lacks Iron, Encodes a Manganese-dependent Superoxide Dismutase Essential for Resistance to Streptonigrin. Journal of Biological Chemistry, 12 Apr. 2012. Web. 17 Apr. 2016. </ref>
Research Question: Why is the bacterium so good at evading the host's immune response? <ref>[http://www.jbc.org/content/early/2012/04/12/jbc.M112.344903.full.pdf+htm]=Troxell, Bryan, Haijun Xu, and Frank Yang. "Borrelia Burgdorferi, a Pathogen That Lacks Iron, Encodes a Manganese-dependent Superoxide Dismutase Essential for Resistance to Streptonigrin." Borrelia Burgdorferi, a Pathogen That Lacks Iron, Encodes a Manganese-dependent Superoxide Dismutase Essential for Resistance to Streptonigrin. Journal of Biological Chemistry, 12 Apr. 2012. Web. 17 Apr. 2016. </ref>

Revision as of 03:26, 26 April 2016

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Section

A scanning electron micrograph of a cluster Borrelia burgdorferi bacteria. Micrograph taken by Claudia Molins at the CDC in 2011. [http://phil.cdc.gov/phil/details.asp?pid=13176}.
Diagram of spirochete showing the flagella and the flagellar motor in between the outer and inner membrane. [http://www.sciencedirect.com/science/article/pii/S1369527415001368
Diagram of B. burgendorferi life cycle and transmission from tick host to other organisms. [http://www.nature.com/nrmicro/journal/v10/n2/fig_tab/nrmicro2714_F1.html

Research Question: Why is the bacterium so good at evading the host's immune response? [1]

Section 1

Section 2

Section 3

Section 4

Conclusion

References

  1. [1]=Troxell, Bryan, Haijun Xu, and Frank Yang. "Borrelia Burgdorferi, a Pathogen That Lacks Iron, Encodes a Manganese-dependent Superoxide Dismutase Essential for Resistance to Streptonigrin." Borrelia Burgdorferi, a Pathogen That Lacks Iron, Encodes a Manganese-dependent Superoxide Dismutase Essential for Resistance to Streptonigrin. Journal of Biological Chemistry, 12 Apr. 2012. Web. 17 Apr. 2016.



Authored for BIOL 238 Microbiology, taught by Joan Slonczewski, 2016, Kenyon College.