Burkholderia pseudomallei: Difference between revisions

From MicrobeWiki, the student-edited microbiology resource
No edit summary
Line 30: Line 30:
Describe any interactions with other organisms (included eukaryotes), contributions to the environment, effect on environment, etc.
Describe any interactions with other organisms (included eukaryotes), contributions to the environment, effect on environment, etc.


==Pathology==
Burkholderia pseudomallei is a human and animal pathogen and is the cause of melioidosis, which is a disease native to Southeast Asia and northern Australia. It releases exo and endo toxins but their role in instigating the symptoms of melioidosis is not yet fully understood. Nevertheless, infection is spread through the ingestion or contact of bacteria on open skin wounds or through the inhalation of the aerosolized Burkholderia pseudomallei. Melioidosis can be classified as acute or chronic depending on the incubation time before symptoms appear. It mimics tuberculosis in its ability o lay dormant without showing any symptoms for years. Common symptoms include fever, formation of abscess on various parts of the body such as the brain, osteomyelitis, bacteremia and various diseases of the heart, lungs and kidney such as pneumonia. Burkholderia pseudomallei was thought to have biological warfare potential and it’s virulence is made evident by being listed as a “Category B agent” by the US centers for Disease Control.
How does this organism cause disease?  Human, animal, plant hosts?  Virulence factors, as well as patient symptoms.


==Application to Biotechnology==
==Application to Biotechnology==

Revision as of 09:23, 3 May 2007

A Microbial Biorealm page on the genus Burkholderia pseudomallei

Classification

Higher order taxa

Bacteria; Proteobacteria; Beta Proteobacteria; Burkholderiales; Burkholderiaceae

Species

NCBI: Taxonomy

Burkholderia pseudomallei

Description and significance

Describe the appearance, habitat, etc. of the organism, and why it is important enough to have its genome sequenced. Describe how and where it was isolated. Include a picture or two (with sources) if you can find them.

Genome structure

Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence? Does it have any plasmids? Are they important to the organism's lifestyle?

Cell structure and metabolism

Describe any interesting features and/or cell structures; how it gains energy; what important molecules it produces.

Ecology

Describe any interactions with other organisms (included eukaryotes), contributions to the environment, effect on environment, etc.

Burkholderia pseudomallei is a human and animal pathogen and is the cause of melioidosis, which is a disease native to Southeast Asia and northern Australia. It releases exo and endo toxins but their role in instigating the symptoms of melioidosis is not yet fully understood. Nevertheless, infection is spread through the ingestion or contact of bacteria on open skin wounds or through the inhalation of the aerosolized Burkholderia pseudomallei. Melioidosis can be classified as acute or chronic depending on the incubation time before symptoms appear. It mimics tuberculosis in its ability o lay dormant without showing any symptoms for years. Common symptoms include fever, formation of abscess on various parts of the body such as the brain, osteomyelitis, bacteremia and various diseases of the heart, lungs and kidney such as pneumonia. Burkholderia pseudomallei was thought to have biological warfare potential and it’s virulence is made evident by being listed as a “Category B agent” by the US centers for Disease Control.

Application to Biotechnology

Does this organism produce any useful compounds or enzymes? What are they and how are they used?

Current Research

Enter summaries of the most recent research here--at least three required

References

[Sample reference] Takai, K., Sugai, A., Itoh, T., and Horikoshi, K. "Palaeococcus ferrophilus gen. nov., sp. nov., a barophilic, hyperthermophilic archaeon from a deep-sea hydrothermal vent chimney". International Journal of Systematic and Evolutionary Microbiology. 2000. Volume 50. p. 489-500.

Edited by Jin-Mo O