Effects of Pathogen-Vector Interactions on the Transmission of Dengue Virus: Difference between revisions
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==Viral Replication== | ==Viral Replication== | ||
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[[File:Viral replication and genome.jpg|400px|thumb| | [[File:Viral replication and genome.jpg|400px|thumb|left|Figure ?. DENV (+)ssRNA genome and schematic of viral replication within the host cell.[21]] | ||
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DENV | DENV infection begins at the cellular level when E proteins on the surface of a DENV virion binds to a host cell receptor initiating endocytosis. The high cell tropism of DENV has made the elucidation of a single host cell receptor difficult and the exact host cell receptor or receptors responsible for viral entry remain to found [22]. | ||
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Once endocytosed, DENV escapes the endosome to the cytoplasm where it can immediately begin translation of its genome. Like other (+)ssRNA viruses it must transcribe a negative strand RNA template to transcribe new copies of its genome. Mature DENV capsids are eventually enveloped in host cell membrane and viral E protein when they bud out of the host cell. | |||
Revision as of 17:51, 7 December 2010
Viral Replication
DENV infection begins at the cellular level when E proteins on the surface of a DENV virion binds to a host cell receptor initiating endocytosis. The high cell tropism of DENV has made the elucidation of a single host cell receptor difficult and the exact host cell receptor or receptors responsible for viral entry remain to found [22].
Once endocytosed, DENV escapes the endosome to the cytoplasm where it can immediately begin translation of its genome. Like other (+)ssRNA viruses it must transcribe a negative strand RNA template to transcribe new copies of its genome. Mature DENV capsids are eventually enveloped in host cell membrane and viral E protein when they bud out of the host cell.
