Effects of Pathogen-Vector Interactions on the Transmission of Dengue Virus
From MicrobeWiki, the student-edited microbiology resource
Viral Replication
DENV infection begins at the cellular level when E proteins on the surface of a DENV virion binds to a host cell receptor initiating endocytosis. The high cell tropism of DENV has made the elucidation of a single host cell receptor difficult and the exact host cell receptor or receptors responsible for viral entry remain to found [22].
Once endocytosed, DENV escapes the endosome to the cytoplasm where it can immediately begin translation of its genome. Like other (+)ssRNA viruses it must transcribe a negative strand RNA template to transcribe new copies of its genome. Mature DENV capsids are eventually enveloped in host cell membrane and viral E protein when they bud out of the host cell.
