Faecalibacterium prausnitzii Relating to Gastroenterology Diseases

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Introduction

File:FP.jpg
Magnified 20,000X, this colorized scanning electron micrograph (SEM) depicts a grouping of methicillin resistant Staphylococcus aureus (MRSA) bacteria. See PHIL 617 for a black and white view of this image. Phoro credit: CDC.

By Kayla Arone

Faecalibacterium prausnitzii is a Gram-negative bacterium, non-sporeforming and extremely oxygen sensitive. This type of gut bacteria is the most abundant bacterium in the human gut, accounting for 5-15% of the total bacterial population in the gut. It is very prevalent in human populations as it is detected in 85% of gut samples and F. prausnitzii is considered to be very prevalent in the GI track of humans. Levels of F. prausnitzii differ by age and gender as well with lower levels in women than men. Levels of F. prausnitzii can be first detected around 6-7 months of age and the abundance rises at around 2-3 years old suggesting that there are different evolutionary stages of F. prausnitzii. Decreased F. prausnitzii levels are observed in various forms of different inflammatory bowel disease (IBD), Crohn’s disease (CD), ulcerative colitis (UC), and colorectal cancer (CRC).

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Crohn's Disease

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Link between Faecalibacterium prausnitzii and Crohn’s Disease

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Mechanisms and Interactions

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Research Findings and Future Research

Studies on Faecalibacterium prausnitzii in Crohn’s Patients

Clinical Trials and Theraputic Approaches

Conclusion

References

  1. ↑ 1.0 1.1 Hodgkin, J. and Partridge, F.A. "Caenorhabditis elegans meets microsporidia: the nematode killers from Paris." 2008. PLoS Biology 6:2634-2637.
  2. ↑ Bartlett et al.: Oncolytic viruses as therapeutic cancer vaccines. Molecular Cancer 2013 12:103.



Authored for BIOL 238 Microbiology, taught by Joan Slonczewski,at Kenyon College,2024

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