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Baltimore Classification

Higher order taxa

Viruses; ssRNA positive-strand viruses, no DNA stage; Flaviviridae


Flavivirus, Pestivirus, Hepacivirus

Description and Significance

Flaviviridae contains a myriad of viruses that cause disease in humans. Flaviviridae has a total of 69 pathogens in its rank. The family gets its name from Yellow Fever virus, a type virus of Flaviviridae; flavus means yellow in Latin.

The Flavivirus genus contains several nasty critters that include yellow fever virus, dengue fever virus, and Japanese encephalitis (JE) virus. The pestivirus genus has three serotypes of bovine viral diarrhea, but no human pathogens are yet known. Genus Hepacivirus consists of hepatitis C virus and its relatives. (source: Stanford.edu)

Genome Structure

The genome of Flaviviridae is not segmented and contains a single molecule of linear positive-sense, single-stranded RNA. The complete genome is 9500-12500 nucleotides long. The 5'-end of the genome has a methylated nucleotide cap, or genome-linked protein (VPg). The 3'- terminus has no poly (A) tract but the poly (A) tract is present in some strains of tick-born encephalitis complex of flaviviruses. (source: ICTV dB Descriptions)

Virion Structure of a Flaviviridae

Reproduction Cycle of a (virus name here) in a Host Cell

Viral Ecology & Pathology