HIV Drug Resistance: Difference between revisions

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[[Image:Drugclasses.png|thumb|300px|right|HIV treatment drug classes and their targets]]
[[Image:Drugclasses.png|thumb|300px|right|HIV treatment drug classes and their targets]]
[[Image:HIVlifecycle.png|thumb|300px|right|Overview of the HIV life cycle]]


==HIV-1 Protease==
==HIV-1 Protease==

Revision as of 00:11, 22 April 2014

Introduction


By Lillian Spetrino

HIV-1 Genome
HIV treatment drug classes and their targets
Overview of the HIV life cycle

HIV-1 Protease


HIV-1 Protease

Protease Inhibitors

Protease Inhibitor Resistance

Three-dimensional structure of HIV PR dimer depicting the primary and secondary mutations associated with resistance to protease inhibitors (Johnson et al., 2008). Mutated residues are represented with their Ca atoms and colored red and blue for major and minor mutations, respectively. Active site aspartates and darunavir bound to the active site are represented in sticks. The figure was generated using the structure of highly mutated patient derived HIV PR (Saskova et al., 2009).

Specific Drug Resistance

Resistance Management

Conclusion