HIV Drug Resistance

From MicrobeWiki, the student-edited microbiology resource

Introduction


By Lillian Spetrino

HIV-1 Genome
HIV treatment drug classes and their targets

HIV-1 Protease


HIV-1 Protease

Protease Inhibitors

Protease Inhibitor Resistance

Three-dimensional structure of HIV PR dimer depicting the primary and secondary mutations associated with resistance to protease inhibitors (Johnson et al., 2008). Mutated residues are represented with their Ca atoms and colored red and blue for major and minor mutations, respectively. Active site aspartates and darunavir bound to the active site are represented in sticks. The figure was generated using the structure of highly mutated patient derived HIV PR (Saskova et al., 2009).

Specific Drug Resistance

Resistance Management

Conclusion