Herpes Simplex Virus and Cancer

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Herpes Simplex Virus 1, also known as oral herpes, is responsible for causing sores in the mouth and lip region when infected1. It can be spread by oral secretions such as kissing and sharing objects that have contact with saliva1. It is estimated that up to 90% of people in the United States have had contact with HSV-1 by the age of 502.


Kaposi sarcoma is a type of cancer that can be formed in the lining of the mouth, nose, throat and lymph nodes. Kaposi sarcoma was very common in men of Middle Eastern descent but has now been shown to be common in AIDS patients. However, it has been shown that Kaposi sarcoma is now caused by the Herpes Virus, and the HSV-1 virus also plays a role in the formation of this cancer.


This means that up to 90% of people with HSV-1 have the possibility to develop Kaposi Sarcoma!

HSV-1

Clinical Characterization of HSV-1

A transmission electron micrograph(TEM) of negatively stained Herpes Simplex Virus.By CDC/ Dr. Fred Murphy [Public domain], via Wikimedia Commons]



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Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.
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Genetic Makeup of HSV-1

Karposi Sarcoma


Include some current research in each topic, with at least one figure showing data.


Genome of Karposi Sarcoma

Proteins involved in formation

HSV-1 and Karposi Sarcoma


Include some current research in each topic, with at least one figure showing data.

Pathway to Cancer by HSV-1

Further Reading

[Sample link] Ebola Hemorrhagic Fever—Centers for Disease Control and Prevention, Special Pathogens Branch

References

[Sample reference] Takai, K., Sugai, A., Itoh, T., and Horikoshi, K. "Palaeococcus ferrophilus gen. nov., sp. nov., a barophilic, hyperthermophilic archaeon from a deep-sea hydrothermal vent chimney". International Journal of Systematic and Evolutionary Microbiology. 2000. Volume 50. p. 489-500.

Edited by (your name here), a student of Nora Sullivan in BIOL168L (Microbiology) in The Keck Science Department of the Claremont Colleges Spring 2014.