Natural Killer Cell: Difference between revisions
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[[Image:NK.cells.EM.LM.jpg|thumb|300px|right|Natural killer cells (NK cells) under light microscopy (A) and electron microscopy (B). In <i>Characterization of a Novel Human Natural Killer-Cell Line (NK-YS) Established From Natural Killer Cell Lymphoma/Leukemia Associated With Epstein-Barr Virus Infection (Tsuchiyama J. et al. 1998)</i>. Link:https://ashpublications.org/blood/article/92/4/1374/247309/Characterization-of-a-Novel-Human-Natural-Killer]] | [[Image:NK.cells.EM.LM.jpg|thumb|300px|right|Natural killer cells (NK cells) under light microscopy (A) and electron microscopy (B). In <i>Characterization of a Novel Human Natural Killer-Cell Line (NK-YS) Established From Natural Killer Cell Lymphoma/Leukemia Associated With Epstein-Barr Virus Infection (Tsuchiyama J. et al. 1998)</i>. Link:https://ashpublications.org/blood/article/92/4/1374/247309/Characterization-of-a-Novel-Human-Natural-Killer]] | ||
Natural killer cells (NK cells) are a type of granular cytotoxic lymphocytes that are non-adherent and non-phagocytic. NK cells were originally defined as a subset of lymphocytes that have natural cytotoxic activity against certain types of tumorous cells and endogenous type-C viruses in mice. Natural cytotoxicity refers to the fact that they can rapidly cause tumor cells’ lyses in the absence of any previous stimulation | Natural killer cells (NK cells) are a type of granular cytotoxic lymphocytes that are non-adherent and non-phagocytic. NK cells were originally defined as a subset of lymphocytes that have natural cytotoxic activity against certain types of tumorous cells and endogenous type-C viruses in mice. Natural cytotoxicity refers to the fact that they can rapidly cause tumor cells’ lyses in the absence of any previous stimulation <ref>Herberman, R. B., Nunn, M. E., Holden, H. T. and Lavrin, D. H. (1975), Natural cytotoxic rectivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells. Int. J. Cancer, 16: 230-239. doi:10.1002/ijc.2910160205</ref>,<ref>Herberman, R. B., Nunn, M. E. and Lavrin, D. H. (1975), Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity. Int. J. Cancer, 16: 216-229. doi:10.1002/ijc.2910160204</ref>. They were first named in an article in 1976 <ref>WOLFE, S., TRACEY, D. & HENNEY, C. Induction of “natural killer” cells by BCG. Nature 262, 584–586 (1976) doi:10.1038/262584a0</ref> and later categorized as part of the innate immune system due to their morphology, origin (bone marrow), and lack of antigen-specific receptors (such as those on T and B-cells’ surfaces) and their respective genes.<ref>Eidenschenk, C., Dunne, J., Jouanguy, E., Fourlinnie, C., Gineau, L., Bacq, D., … Feighery, C. (2006). A Novel Primary Immunodeficiency with Specific Natural-Killer Cell Deficiency Maps to the Centromeric Region of Chromosome 8. The American Journal of Human Genetics, 78(4), 721–727. doi: 10.1086/503269</ref>,<ref>Trinchieri, G. Biology of natural keller cells. Adv. Immunology. Volume 47, 187-376 (1989). doi: 10.1016/S0065-2776(08)60664-1</ref> | ||
[[Image:marburgvirus.jpg|thumb|300px|right|Colony of Marburg virus. Transmission electron microscope image taken by Dr. Tom Geisbert]] | [[Image:marburgvirus.jpg|thumb|300px|right|Colony of Marburg virus. Transmission electron microscope image taken by Dr. Tom Geisbert]] |
Revision as of 04:19, 2 December 2019
Overview
Natural killer cells (NK cells) are a type of granular cytotoxic lymphocytes that are non-adherent and non-phagocytic. NK cells were originally defined as a subset of lymphocytes that have natural cytotoxic activity against certain types of tumorous cells and endogenous type-C viruses in mice. Natural cytotoxicity refers to the fact that they can rapidly cause tumor cells’ lyses in the absence of any previous stimulation [1],[2]. They were first named in an article in 1976 [3] and later categorized as part of the innate immune system due to their morphology, origin (bone marrow), and lack of antigen-specific receptors (such as those on T and B-cells’ surfaces) and their respective genes.[4],[5]
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Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.
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References
- ↑ Herberman, R. B., Nunn, M. E., Holden, H. T. and Lavrin, D. H. (1975), Natural cytotoxic rectivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells. Int. J. Cancer, 16: 230-239. doi:10.1002/ijc.2910160205
- ↑ Herberman, R. B., Nunn, M. E. and Lavrin, D. H. (1975), Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity. Int. J. Cancer, 16: 216-229. doi:10.1002/ijc.2910160204
- ↑ WOLFE, S., TRACEY, D. & HENNEY, C. Induction of “natural killer” cells by BCG. Nature 262, 584–586 (1976) doi:10.1038/262584a0
- ↑ Eidenschenk, C., Dunne, J., Jouanguy, E., Fourlinnie, C., Gineau, L., Bacq, D., … Feighery, C. (2006). A Novel Primary Immunodeficiency with Specific Natural-Killer Cell Deficiency Maps to the Centromeric Region of Chromosome 8. The American Journal of Human Genetics, 78(4), 721–727. doi: 10.1086/503269
- ↑ Trinchieri, G. Biology of natural keller cells. Adv. Immunology. Volume 47, 187-376 (1989). doi: 10.1016/S0065-2776(08)60664-1
- ↑ Hodgkin, J. and Partridge, F.A. "Caenorhabditis elegans meets microsporidia: the nematode killers from Paris." 2008. PLoS Biology 6:2634-2637.
- ↑ Bartlett et al.: Oncolytic viruses as therapeutic cancer vaccines. Molecular Cancer 2013 12:103.
Edited by [Minh Pham], student of Joan Slonczewski for BIOL 116 Information in Living Systems, 2019, Kenyon College.