Potential Therapeutics Isolated from Salinispora: Difference between revisions
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<br>Rather than designing synthetic drugs, some researchers are exploring natural sources for medical treatments or as models for future synthetic treatments. One promising source includes the recently discovered Salinispora bacteria, belonging to the order Actinomycetales (also known as actinomycetes). This order includes many species that have contributed to today’s naturally occurring antibiotics. It was originally believed that the gram positive Actinomycetales only existed in soil habitats, and that any actinomycetes found in marine environments came from spores produced by terrestrial species (1). However, in search of new actinomycetes as possible dug sources, Jensen and Fenical of the Scripps Institution of Oceanography in the late 1980s discovered actinomycetes that required seawater for growth (2). In 2002, the separate strains of marine origin were found in tropical and subtropical sediments, and classified under the genus Salinispora, belonging to the family Micromonosporaceae. Two species have been formally identified as Salinispora arenicola and Salinispora tropica, while a third species of Salinispora pacifica is being studied (2,3). The Salinispora bacteria have, like the rest of their order, a variety of secondary metabolites that may be useful in the pharmeceutical industry, including the proteasome inhibitor salinosporamide A, which has entered the first phase of clinical trials as a cancer treatment (4). While the functions of some Salinispora metabolites are still unknown, these bacteria may offer researchers a source of new antibiotics and cancer treating drugs.<br> | <br>Rather than designing synthetic drugs, some researchers are exploring natural sources for medical treatments or as models for future synthetic treatments. One promising source includes the recently discovered Salinispora bacteria, belonging to the order Actinomycetales (also known as actinomycetes). This order includes many species that have contributed to today’s naturally occurring antibiotics. It was originally believed that the gram positive Actinomycetales only existed in soil habitats, and that any actinomycetes found in marine environments came from spores produced by terrestrial species (1). However, in search of new actinomycetes as possible dug sources, Jensen and Fenical of the Scripps Institution of Oceanography in the late 1980s discovered actinomycetes that required seawater for growth (2). In 2002, the separate strains of marine origin were found in tropical and subtropical sediments, and classified under the genus Salinispora, belonging to the family Micromonosporaceae. Two species have been formally identified as Salinispora arenicola and Salinispora tropica, while a third species of Salinispora pacifica is being studied (2,3). The Salinispora bacteria have, like the rest of their order, a variety of secondary metabolites that may be useful in the pharmeceutical industry, including the proteasome inhibitor salinosporamide A, which has entered the first phase of clinical trials as a cancer treatment (4). While the functions of some Salinispora metabolites are still unknown, these bacteria may offer researchers a source of new antibiotics and cancer treating drugs.<br> | ||
== | ==Salinispora: Characterization & Genome== | ||
<br>Include some current research in each topic, with at least one figure showing data.<br> | <br>Include some current research in each topic, with at least one figure showing data.<br> | ||
== | ==Salinosporamide A== | ||
<br>Include some current research in each topic, with at least one figure showing data.<br> | <br>Include some current research in each topic, with at least one figure showing data.<br> | ||
== | ==Saliniketal== | ||
<br>Include some current research in each topic, with at least one figure showing data.<br> | <br>Include some current research in each topic, with at least one figure showing data.<br> | ||
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[Sample reference] [http://ijs.sgmjournals.org/cgi/reprint/50/2/489 Takai, K., Sugai, A., Itoh, T., and Horikoshi, K. "''Palaeococcus ferrophilus'' gen. nov., sp. nov., a barophilic, hyperthermophilic archaeon from a deep-sea hydrothermal vent chimney". ''International Journal of Systematic and Evolutionary Microbiology''. 2000. Volume 50. p. 489-500.] | [Sample reference] [http://ijs.sgmjournals.org/cgi/reprint/50/2/489 Takai, K., Sugai, A., Itoh, T., and Horikoshi, K. "''Palaeococcus ferrophilus'' gen. nov., sp. nov., a barophilic, hyperthermophilic archaeon from a deep-sea hydrothermal vent chimney". ''International Journal of Systematic and Evolutionary Microbiology''. 2000. Volume 50. p. 489-500.] | ||
Edited by student of [mailto:slonczewski@kenyon.edu Joan Slonczewski] for [http://biology.kenyon.edu/courses/biol238/biol238syl09.html BIOL 238 Microbiology], 2009, [http://www.kenyon.edu/index.xml Kenyon College]. | Edited by a student of [mailto:slonczewski@kenyon.edu Joan Slonczewski] for [http://biology.kenyon.edu/courses/biol238/biol238syl09.html BIOL 238 Microbiology], 2009, [http://www.kenyon.edu/index.xml Kenyon College]. |
Revision as of 03:21, 14 April 2009
Introduction
Rather than designing synthetic drugs, some researchers are exploring natural sources for medical treatments or as models for future synthetic treatments. One promising source includes the recently discovered Salinispora bacteria, belonging to the order Actinomycetales (also known as actinomycetes). This order includes many species that have contributed to today’s naturally occurring antibiotics. It was originally believed that the gram positive Actinomycetales only existed in soil habitats, and that any actinomycetes found in marine environments came from spores produced by terrestrial species (1). However, in search of new actinomycetes as possible dug sources, Jensen and Fenical of the Scripps Institution of Oceanography in the late 1980s discovered actinomycetes that required seawater for growth (2). In 2002, the separate strains of marine origin were found in tropical and subtropical sediments, and classified under the genus Salinispora, belonging to the family Micromonosporaceae. Two species have been formally identified as Salinispora arenicola and Salinispora tropica, while a third species of Salinispora pacifica is being studied (2,3). The Salinispora bacteria have, like the rest of their order, a variety of secondary metabolites that may be useful in the pharmeceutical industry, including the proteasome inhibitor salinosporamide A, which has entered the first phase of clinical trials as a cancer treatment (4). While the functions of some Salinispora metabolites are still unknown, these bacteria may offer researchers a source of new antibiotics and cancer treating drugs.
Salinispora: Characterization & Genome
Include some current research in each topic, with at least one figure showing data.
Salinosporamide A
Include some current research in each topic, with at least one figure showing data.
Saliniketal
Include some current research in each topic, with at least one figure showing data.
Conclusion
Overall paper length should be 3,000 words, with at least 3 figures.
References
Edited by a student of Joan Slonczewski for BIOL 238 Microbiology, 2009, Kenyon College.