Proteus mirabilis

A Microbial Biorealm page on the genus Proteus mirabilis

Classification

Higher order taxa

Domain; Phylum; Class; Order; family [Others may be used. Use NCBI link to find]

Species

NCBI: Taxonomy

Genus species

Genome structure

The genome sequence of Proteus mirabilis was completed in March 28, 2008 by Melanie M. Pearson identifying more than 3,658 coding sequences with 7 rRNA loci (Pearson etc. al, 2008). The genome’s total length is 4.063 Mb with a 28.8% GC content. P. mirabilis also carries a single plasmid with 36, 298 nucleotides. The plasmid itself does not contain any virulence genes but it may contain a bacteriocin and its immunity system Within the genome is a genomic island involved in pathogenicity that codes for a type III secretion system comprising 24 genes used to inject bacterial proteins into a host genome. This type III system appears to be incorporated through horizontal gene transfer and is noted for its relatively smaller G+C content compared with the rest of the genome (Pearson etc. al, 2008). The genome sequence encodes 17 different types of fimbriae as well as a 54 kb flagellar regulon. The flagella made by the strain all come from a single locus. This information is characterized for a specific uropathogenic strain of P. mirabilis, HI4320. It is the first completed sequence of the bacterium out of more than 75 known strains that were identified using one dimensional SDS PAGE of cellular proteins mostly from human origin (Holmes etc. al, 2008).

References

Edited by Isioma Agboli, Michael Cao, Janice Love, and Fatima Morales