R. gnavus: Difference between revisions
| Line 38: | Line 38: | ||
Crost, E. H., Coletto, E., Bell, A., & Juge, N. (2023). Ruminococcus gnavus: Friend or foe for human health. FEMS Microbiology Reviews, 47(2). https://doi.org/10.1093/femsre/fuad014 | Crost, E. H., Coletto, E., Bell, A., & Juge, N. (2023). Ruminococcus gnavus: Friend or foe for human health. FEMS Microbiology Reviews, 47(2). https://doi.org/10.1093/femsre/fuad014 | ||
[ | [Henke, M. T., Kenny, D. J., Cassilly, C. D., Vlamakis, H., Xavier, R. J., & Clardy, J. (2019, June 25). ruminococcus gnavus, a member of the human gut microbiome associated with crohn’s disease, produces an inflammatory polysaccharide. Proceedings of the National Academy of Sciences of the United States of America. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601261/] | ||
==Author== | ==Author== | ||
Page authored by Chris Blackwell, student of Prof. Bradley Tolar at UNC Wilmington. | Page authored by Chris Blackwell, student of Prof. Bradley Tolar at UNC Wilmington. | ||
Revision as of 00:08, 16 November 2023
Classification
Bacteria (Domain); Firmicutes (Phylum); Clostridia (Class); Clostridiales (Order); Lachnospiraceae (Family); Mediterraneibacter (Genus)
Species
|
NCBI: [1] |
Ruminococcus gnavus
Description and Significance
Ruminococcus gnavus is a Gram-positive obligate anaerobe bacterium discovered first in the human gastrointestinal tract. Despite its name it is actually a part of the genus Mediterraneibacter, although retaining its Ruminococcus name for study purposes.
R. gnavus is considered a part of the normal human gut microbiome in children and adults. It has been suggested that it has a role in priming the gut microbiota in association with standard weight gain velocity in infants.
Ruminococcus gnavus is one of few micorbiota bacterium that persists at a consistent level from infancy to throughout adulthood. Studies have shown that R.gnavus is a key biomarker of health and diseases with certain immune/metabolic properties, making it an important bacterium to understand.
Genome Structure
Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence?
Cell Structure, Metabolism and Life Cycle
Interesting features of cell structure; how it gains energy; what important molecules it produces.
Ecology and Pathogenesis
Habitat; symbiosis; biogeochemical significance; contributions to environment.
If relevant, how does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.
There are a multitude of studies that show a large positive association between Crohn's disease and Ruminococcus gnavus populations. R. gnavus populations skyrocket during flare ups in Crohn's disease patients. R. gnavus produces an inflammatory glucorhamnan polysaccharide that triggers the production of inflammatory cytokines.
Patients experiencing Crohn's disease and an increase in R. gnavus experience symptoms such as abdominal pain, diarrhea, and bloody stool. Patients experiencing extreme symptoms may face inflammation of the eyes, skin, and spine.
References
Crost, E. H., Coletto, E., Bell, A., & Juge, N. (2023). Ruminococcus gnavus: Friend or foe for human health. FEMS Microbiology Reviews, 47(2). https://doi.org/10.1093/femsre/fuad014
[Henke, M. T., Kenny, D. J., Cassilly, C. D., Vlamakis, H., Xavier, R. J., & Clardy, J. (2019, June 25). ruminococcus gnavus, a member of the human gut microbiome associated with crohn’s disease, produces an inflammatory polysaccharide. Proceedings of the National Academy of Sciences of the United States of America. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601261/]
Author
Page authored by Chris Blackwell, student of Prof. Bradley Tolar at UNC Wilmington.
