Salmonella enterica serovar Paratyphi
Etiology/Bacteriology
Taxonomy
Description
Pathogenesis
Transmission
Infectious dose, incubation, and colonization
Epidemiology
Virulence factors
Clinical features
Symptoms/Morbidity
Mortality
Diagnosis
Treatment
Prevention
Risk Avoidance
The incidence of enteric fever is most strongly correlated with poor sanitation and lack of clean drinking water. This is because Salmonella Paratyphi is transmitted through consumption of contaminated food or water. Therefore, in order to decrease the incidence of this disease, it is important to avoid the consumption of contaminated food or water, provide education about food and water safety, and promote basic sanitation. [1] [2]
Immunization
Host Immune Response
When the body is infected by Salmonella Paratyphi, a humoral immune response is mounted. The response primarily takes place in the intestinal tract, since the gut is the first line of defense against enteric diseases [3]. Based on research performed with the Ty21a-vaccine, after the host was exposed to the oral vaccine, there was a predominance of IgA antibodies. As part of the immune response, it is believed that after the B cells arrive in the intestinal lining, they undergo isotype switching from IgM to IgA. This specific immunoglobulin isotype is produced to stimulate the destruction of Salmonella bacteria. Other research indicates that a cell-mediated response is also activated upon infection. [2]
References
References
Created by {insert your names here}, students of Tyrrell Conway at the University of Oklahoma.
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