Difference between revisions of "Suppression of Peptidoglycan Remodeling"

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<br>By [Frank Zhao] <br>
 
<br>By [Frank Zhao] <br>
 
==Introduction==
 
==Introduction==
[[Image:Gram-negative.png|thumb|500px|right|This illustration depicts a three-dimensional (3D), computer-generated image, of a group of Gram-positive, Streptococcus agalactiae (group B Streptococcus) bacteria. The photo credit for this image belongs to Alissa Eckert, who is a medical illustrator at the [http://www.cdc.gov/ CDC].]]
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[[Image:Gram-negative.png|thumb|500px|right|This illustration depicts a three-dimensional (3D), computer-generated image, of a group of Gram-positive, Streptococcus agalactiae (group B Streptococcus) bacteria. The photo credit for this image belongs to Alissa Eckert, who is a medical illustrator at the [https://images.app.goo.gl/9aCkeporsrGyCMiA9].]]
  
 
<br>At right is a sample image insertion.  It works for any image uploaded anywhere to MicrobeWiki.<br><br>The insertion code consists of:
 
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Revision as of 04:30, 7 April 2021

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By [Frank Zhao]

Introduction

This illustration depicts a three-dimensional (3D), computer-generated image, of a group of Gram-positive, Streptococcus agalactiae (group B Streptococcus) bacteria. The photo credit for this image belongs to Alissa Eckert, who is a medical illustrator at the [1].


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Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC. Every image requires a link to the source.
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Peptidoglycan is a polymer made of sugars and amino acids that forms a layer outside the plasma membrane of bacterial cells. Peptidoglycans are cross-linked by peptides, serving as the cell wall that protects bacteria from the environment. Peptidoglycan limits the volume of the cell and thus it generates turgor pressure as the water rushes into the cell. Gram-positive bacteria obtain thicker peptidoglycan layer than Gram-negative bacteria but this layer is crucial to the survival of both types of bacteria. Many antibiotics target this component to kill the bacteria. For example, penicillin binds to penicillin binding proteins and inhibits the synthesis of peptidoglycan, weakening the cell wall of bacteria. It has been discovered that a new mechanism could be used by antibiotics on peptidoglycan— blocking the action of autolysins, a peptidoglycan hydrolases that is essential for remodeling of the bacterial cell wall during growth. Studying how this new mechanism work could give us insight into developing new antibiotics againt resistance strains.
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Authored for BIOL 238 Microbiology, taught by Joan Slonczewski, 2021, Kenyon College.