The Role of Clostridium perfringens Toxins in Gas Gangrene: Difference between revisions
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[[Image:PFO.jpeg|thumb| | [[Image:PFO.jpeg|thumb|350px|right|Perfringolysin O binding with the phospholipid bilayer. Courtesy of <i>Toxins</i> Journal, 2015, Vol. 7, Issue 5, 1702-1721, published on MDPI: Open Access (http://www.mdpi.com/2072-6651/7/5/1702/htm.]] | ||
==How Do These Toxins Help <i>C. perfringens</i> Persist and Spread in the Body?== | ==How Do These Toxins Help <i>C. perfringens</i> Persist and Spread in the Body?== |
Revision as of 19:59, 25 April 2016
What is Gas Gangrene?
By Marysol Arce
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Alpha Toxin (PLC)
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All strains of C. perfringens produce the alpha toxin, also called CPA or PLC. The alpha toxin cleaves molecules from the surface the host cell's’ phospholipid bilayers and disrupts the membrane’s functions, which then promotes cell lysis and death.
Perfringolysin O (PFO)
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How Do These Toxins Help C. perfringens Persist and Spread in the Body?
Include some current research, with at least one figure showing data.