The Role of Clostridium perfringens Toxins in Gas Gangrene: Difference between revisions

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All strains of C. perfringens produce the alpha toxin, also called CPA or PLC.  The alpha toxin cleaves molecules from the surface the host cell's’ phospholipid bilayers and disrupts the membrane’s functions, which then promotes cell lysis and death.
All strains of C. perfringens produce the alpha toxin, also called CPA or PLC.  The alpha toxin cleaves molecules from the surface the host cell's’ phospholipid bilayers and disrupts the membrane’s functions, which then promotes cell lysis and death.


[[Image:Alpha_toxin_on_membrane.jpeg|thumb|300px|right|Alpha toxin attachment and insertion into host cell membrane. Courtesy of <i>The Jounal of Biochemistry</i>, 2004, Vol. 136, Issue 5,  569-574, published on Oxford Journals (http://jb.oxfordjournals.org/content/136/5/569.long.]]
[[Image:Alpha_toxin_on_membrane.jpeg|thumb|350px|right|Alpha toxin attachment and insertion into host cell membrane. Courtesy of <i>The Jounal of Biochemistry</i>, 2004, Vol. 136, Issue 5,  569-574, published on Oxford Journals (http://jb.oxfordjournals.org/content/136/5/569.long.]]


==Perfringolysin O (PFO)==
==Perfringolysin O (PFO)==

Revision as of 19:59, 25 April 2016

What is Gas Gangrene?


By Marysol Arce


A patient's right thigh severely affected by gas gangrene. Courtesy of Cases Journal, 2008, Vol. 1, Issue 252, published on BioMed Central (http://casesjournal.biomedcentral.com/articles/10.1186/1757-1626-1-252.




Other examples:
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Superscript: Fe3+


Introduce the topic of your paper. What is your research question? What experiments have addressed your question? Applications for medicine and/or environment?


A citation code consists of a hyperlinked reference within "ref" begin and end codes. [1]

Alpha Toxin (PLC)

Include some current research, with at least one figure showing data.

Every point of information REQUIRES CITATION using the citation tool shown above.

All strains of C. perfringens produce the alpha toxin, also called CPA or PLC. The alpha toxin cleaves molecules from the surface the host cell's’ phospholipid bilayers and disrupts the membrane’s functions, which then promotes cell lysis and death.

Alpha toxin attachment and insertion into host cell membrane. Courtesy of The Jounal of Biochemistry, 2004, Vol. 136, Issue 5, 569-574, published on Oxford Journals (http://jb.oxfordjournals.org/content/136/5/569.long.

Perfringolysin O (PFO)

Include some current research, with at least one figure showing data.


Perfringolysin O binding with the phospholipid bilayer. Courtesy of Toxins Journal, 2015, Vol. 7, Issue 5, 1702-1721, published on MDPI: Open Access (http://www.mdpi.com/2072-6651/7/5/1702/htm.

How Do These Toxins Help C. perfringens Persist and Spread in the Body?

Include some current research, with at least one figure showing data.

Conclusion

References

Schröpfer, Engelbert, Stephan Rauthe, and Thomas Meyer. "Diagnosis and Misdiagnosis of Necrotizing Soft Tissue Infections: Three Case Reports." Cases Journal 1.252 (2008): n. pag. BioMed Central. Web. 21 Apr. 2016.

Awad, Milena M., Darren M. Ellemor, Richard L. Boyd, John J. Emmins, and Julian I. Rood. "Synergistic Effects of Alpha-Toxin and Perfringolysin O in Clostridium Perfringens-Mediated Gas Gangrene." Infection and Immunity 69.12 (2001): 7904-910. American Society for Microbiology. Web. 18 Apr. 2016.

  1. ↑ Zhao, Ge, Marcia L. Usui, Soyeon I. Lippman, Garth A. James, Philip S. Stewart, Philip Fleckman, and John E. Olerud. "Biofilms and Inflammation in Chronic Wounds." 2013. Advances In Wound Care 2(7):389-399. DOI: 10.1089/wound.2012.0381
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