The Role of Clostridium perfringens Toxins in Gas Gangrene
What is Gas Gangrene?
By Marysol Arce
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Alpha Toxin (PLC)
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All strains of C. perfringens produce the alpha toxin, also called CPA or PLC. The alpha toxin cleaves molecules from the surface the host cell's’ phospholipid bilayers and disrupts the membrane’s functions, which then promotes cell lysis and death.
Perfringolysin O (PFO)
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How Do These Toxins Help C. perfringens Persist and Spread in the Body?
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