The Role of Viral Proteins in Epstein-Barr Virus Induced Disease: Difference between revisions
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==Introduction== | ==Introduction== | ||
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The Epstein-Barr Virus (EBV) is a common human herpes virus that can cause both infectious mononucleosis and lymphoproliferative disease. EBV is unique in that it infects about 95% of the adult population between 35-40 years old in the U.S. [1]. EBV is associated with cancers such as Burkitt’s Lymphoma and nasopharyngeal carcinoma [1,2]. The virus is capable of infection of host B-cells which primarily occurs via a non-lytic mechanism [2]. During this latent process, virus-derived nuclear proteins (EBNAs) and membrane proteins (LMPs) are expressed by infected host cells [2]. An advancing area of research is aimed at understanding how LMP proteins may play a role in lymphoproliferative disease. LMP-1 is one of these membranous proteins, and has been shown to cause induce indefinite, tumorigenic, replication in infected B-cells [3]. The mechanism by which this occurs is a field of study vital to a deeper understanding of the pathogenicity of EBV. | The Epstein-Barr Virus (EBV) is a common human herpes virus that can cause both infectious mononucleosis and lymphoproliferative disease. EBV is unique in that it infects about 95% of the adult population between 35-40 years old in the U.S. [1]. EBV is associated with cancers such as Burkitt’s Lymphoma and nasopharyngeal carcinoma [1,2]. The virus is capable of infection of host B-cells which primarily occurs via a non-lytic mechanism [2]. During this latent process, virus-derived nuclear proteins (EBNAs) and membrane proteins (LMPs) are expressed by infected host cells [2]. An advancing area of research is aimed at understanding how LMP proteins may play a role in lymphoproliferative disease. LMP-1 is one of these membranous proteins, and has been shown to cause induce indefinite, tumorigenic, replication in infected B-cells [3]. The mechanism by which this occurs is a field of study vital to a deeper understanding of the pathogenicity of EBV. | ||
==References== | |||
[1]"Epstein-Barr Virus and Infectious Mononucleosis." Centers for Disease Control. http://www.cdc.gov/ncidod/diseases/ebv.htm. Accessed: 11/3/12. | |||
[2] | |||
Revision as of 15:57, 13 November 2012
Introduction
The Epstein-Barr Virus (EBV) is a common human herpes virus that can cause both infectious mononucleosis and lymphoproliferative disease. EBV is unique in that it infects about 95% of the adult population between 35-40 years old in the U.S. [1]. EBV is associated with cancers such as Burkitt’s Lymphoma and nasopharyngeal carcinoma [1,2]. The virus is capable of infection of host B-cells which primarily occurs via a non-lytic mechanism [2]. During this latent process, virus-derived nuclear proteins (EBNAs) and membrane proteins (LMPs) are expressed by infected host cells [2]. An advancing area of research is aimed at understanding how LMP proteins may play a role in lymphoproliferative disease. LMP-1 is one of these membranous proteins, and has been shown to cause induce indefinite, tumorigenic, replication in infected B-cells [3]. The mechanism by which this occurs is a field of study vital to a deeper understanding of the pathogenicity of EBV.
References
[1]"Epstein-Barr Virus and Infectious Mononucleosis." Centers for Disease Control. http://www.cdc.gov/ncidod/diseases/ebv.htm. Accessed: 11/3/12.
[2]
