User:S4350566: Difference between revisions
| Line 15: | Line 15: | ||
==Description and significance== | ==Description and significance== | ||
Porphyromonas gingivalis is a Gram-negative anaerobe. It is a major causative agent of the initiation and progression of periodontal disease, a main cause of tooth loss <sup>[[#References|[1]]]</sup>. P. gingivalis is an opportunistic pathogen found in the subgingival sulcus of the human oral cavity (<sup>[[#References|[2]]]</sup>. Along with T. denticola and T. forsythia, P. gingivalis forms the red bacterial complex which is often seen in advanced periodontal lesions (<sup>[[#References|[2]]]</sup>. P. gingivalis is strongly associated with gingival recession, increased sulcular pocket depth and bleeding upon probing (Molecular analysis of bacteria in periodontitis: evaluation of clone libraries, novel phylotypes and putative pathogens). The bacterium has also been found in healthy individuals, at a prevalence of 10-25%. P. gingivalis is found in those with periodontitis at a prevalence of 79%-90%. Epidemiological studies have shown that strains vary in association with human disease and virulence in animal models. Strains W83, W50, ATCC 49417, A7A1 have been classified as virulence, whereas avirulent strains include 381, 33277 and 23A4 (<sup>[[#References|[4]]]</sup>. | |||
==Genome structure== | ==Genome structure== | ||
Revision as of 04:28, 23 September 2016
Louise Parker Bench D 31/08/2016 [1]
Classification
Higher order taxa
Bacteria – Domain – Bacteroidetes – Bacteroidetes – Bacteroidales – Porphyromonadaceae – Porphyromonas
Species
Species: Porphyromonas gingivalis
Strain: strain 2561 = ATCC 33277= CCUG 25893 = CCUG 25928 = CIP 103683 = DSM 20709 = JCM 12257 = NCTC 11834.
Description and significance
Porphyromonas gingivalis is a Gram-negative anaerobe. It is a major causative agent of the initiation and progression of periodontal disease, a main cause of tooth loss [1]. P. gingivalis is an opportunistic pathogen found in the subgingival sulcus of the human oral cavity ([2]. Along with T. denticola and T. forsythia, P. gingivalis forms the red bacterial complex which is often seen in advanced periodontal lesions ([2]. P. gingivalis is strongly associated with gingival recession, increased sulcular pocket depth and bleeding upon probing (Molecular analysis of bacteria in periodontitis: evaluation of clone libraries, novel phylotypes and putative pathogens). The bacterium has also been found in healthy individuals, at a prevalence of 10-25%. P. gingivalis is found in those with periodontitis at a prevalence of 79%-90%. Epidemiological studies have shown that strains vary in association with human disease and virulence in animal models. Strains W83, W50, ATCC 49417, A7A1 have been classified as virulence, whereas avirulent strains include 381, 33277 and 23A4 ([4].
Genome structure
Select a strain for which genome information (e.g. size, plasmids, distinct genes, etc.) is available.
The Porphyromonas gingivalis strain W83 has a 2,343,479bp genome sequence. It has an average G+C content of 48.3%. 1,990 open reading frames were identified in the genome, making up 85% of the genome. 1,075 of these were assigned biological role categories. - (Complete Genome Sequence of the Oral Pathogenic Bacterium Porphyromonas gingivalis Strain W83)Distinct genes
Cell structure and metabolism
Cell wall, biofilm formation, motility, metabolic functions.
Ecology
Aerobe/anaerobe, habitat (location in the oral cavity, potential other environments) and microbe/host interactions.
Pathology
Do these microorganisms cause disease in the oral cavity or elsewhere?
Application to biotechnology
Bioengineering, biotechnologically relevant enzyme/compound production, drug targets,…
Current research
Summarise some of the most recent discoveries regarding this species.
References
3. Molecular analysis of bacteria in periodontitis: evaluation of clone libraries, novel phylotypes and putative pathogens
- ↑ MICR3004
This page is written by Louise Parker for the MICR3004 course, Semester 2, 2016
