User talk:Pmedina0098
Introduction
The National Center for Biotechnology Inforation (NCBI) Microbial Genome Project Database uses five terms to categorize the temperature range an organism grows at, where cryophilic refers to –30° to –2°C, psychrophilic refers to –1° to +10°C, mesophilic refers to +11° to +45°C, thermophilic refers to +46° to 75°C, and hyperthermophilic refers to above +75°C. High temperatures can often denature enzymes and proteins that are vital to an organisms survival. Unlike these types of organisms, thermophiles can survive and thrive at very high temperatures. They found in geothermally heated regions of the Earth like deep-sea hydrothermal vents and the hot springs of Yellowstone National Park. The investigation of thermophilic physiology poses very promising and intriguing contributions to the scientific community. For one, some of the enzymes used in molecular biology, like DNA polymerases, have derived from investigating heat-stable enzymes. In addition, astrobiologists look to understand the structural and genomic correlates of hyoerthermostability in order to give indication to what life may look like on planets hotter than ours.
Research has suggested physical adaptations that allow thermophiles to remain functional and alive at high temperatures. First, increasing the number of salt bridges is a driving force for enhancement of the thermotolerance of proteins from hyperthermophilic microorganisms. Second, research suggests that the replacement of polar noncharged resides by charged ones constitutes a major stabilization mechanisms in the proteins of hyperthermophilic organisms. Third, thermophilic protein sequences are more likely than their mesophilic homologs to have deletions in exposed loop regions.
At right is a sample image insertion. It works for any image uploaded anywhere to MicrobeWiki. The insertion code consists of:
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Filename: PHIL_1181_lores.jpg
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Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.
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Other examples:
Bold
Italic
Subscript: H2O
Superscript: Fe3+
Salt Bridges
Include some current research in each topic, with at least one figure showing data.
At right is a sample image insertion. It works for any image uploaded anywhere to MicrobeWiki. The insertion code consists of:
Double brackets: [[
Filename: PHIL_1181_lores.jpg
Thumbnail status: |thumb|
Pixel size: |300px|
Placement on page: |right|
Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.
Closed double brackets: ]]
Polar Charged Residues
Include some current research in each topic, with at least one figure showing data.
Loop Deletions
Include some current research in each topic, with at least one figure showing data.
GC Content
Include some current research in each topic, with at least one figure showing data.
Conclusion
Overall paper length should be 3,000 words, with at least 3 figures.
References
Edited by (your name here), a student of Nora Sullivan in BIOL187S (Microbial Life) in The Keck Science Department of the Claremont Colleges Spring 2013.
