Globicatella sanguinis

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Classification

Domain; Phylum; Class; Order; family [Others may be used. Use NCBI link to find]

Species

NCBI: [1]

Genus species

Description and Significance

G. sanguinis is cocci shaped. Its cellular arrangement consists of pairs and short chains. G. sanguinis thrive in the human body. It is a pathogen that causes infection within the bloodstream, central nervous system, and the urinary tract. It is important to conduct research and expand our knowledge of G. sanguinis because it is a pathogen that is difficult to identify phenotypically. It is becoming more prevalent within different diseases in the body.

Genome Structure

Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence?

Cell Structure, Metabolism and Life Cycle

Cell structure of Globicatella sanguinis (G. sanguinis) is a gram-positive bacteria. G. sanguinis metabolizes through peptide catabolic energy, active glycolytic, and heterolactic fermentation. G. sanguinis grow anaerobically and are also alpha-hemolytic, meaning that they have the ability to break down red blood cells. G. sanguinis is catalase negative.

Ecology and Pathogenesis

Habitat; symbiosis; biogeochemical significance; contributions to environment.

If relevant, how does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.

Symptoms of infection:

    -meningeoencephalitis

References

Miller, A. O., Buckwalter, S. P., Henry, M. W., Wu, F., Maloney, K. F., Abraham, B. K., Hartman, B. J., Brause, B. D., Whittier, S., Walsh, T. J., & Schuetz, A. N. (2017). Globicatella sanguinis Osteomyelitis and Bacteremia: Review of an Emerging Human Pathogen with an Expanding Spectrum of Disease. Open forum infectious diseases, 4(1), ofw277. https://doi.org/10.1093/ofid/ofw277

Shewmaker PLSteigerwalt AG, Shealey L, Weyant R, Facklam RR.2001.DNA Relatedness, Phenotypic Characteristics, and Antimicrobial Susceptibilities of Globicatella sanguinis Strains. J Clin Microbiol39:.https://doi.org/10.1128/JCM.39.11.4052-4057.2001

Vela, A I et al. “Meningoencephalitis associated with Globicatella sanguinis infection in lambs.” Journal of clinical microbiology vol. 38,11 (2000): 4254-5. doi:10.1128/JCM.38.11.4254-4255.2000

1. Yu Y, Tsitrin T, Bekele S, et al. Aerococcus urinae and Globicatella sanguinis Persist in Polymicrobial Urethral Catheter Biofilms Examined in Longitudinal Profiles at the Proteomic Level. Biochemistry Insights. 2019;12. doi:10.1177/1178626419875089

Author

Page authored by Adisen Ames, Caleb Barker, Tasnim Goubar, & Samantha Kopyar, students of Prof. Bradley Tolar at UNC Wilmington.