Globuloviridae

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Legend. Image credit: Name or Publication.

Classification

Domain; Phylum; Class; Order; family [Others may be used. Use NCBI link to find]

Species

NCBI: [1]

Genus species

Description and Significance

The Globuloviridae family comprises spherical, enveloped viruses with linear, double-stranded DNA genomes ranging from 21 to 28 kilobase pairs. These viruses infect hyperthermophilic archaea, specifically the genera Pyrobaculum and Thermoproteus, which thrive in extreme geothermal environments. The virions are about 70-100 nm in diameter and feature a lipid-containing envelope and a helical nucleoprotein core. Notably, globuloviruses do not cause the lysis of their host cells, and their genomes do not integrate into the host’s chromosome. The significance of Globuloviridae lies in their role in the ecology of extreme environments and their contribution to our understanding of virus-host interactions under extreme conditions. Studying these viruses can provide insights into the limits of life on Earth and the potential for life in similar extreme environments elsewhere in the universe.

Genome Structure

Globuloviridae have a genome size of roughly 21,000 to 28,000 base pairs and contain between 38 and 48 open reading frames depending on specific species. Only 15 open reading frames are shared between the Pyrobaculum and Thermoproteus Tenax spherical virus species. The genome consists of linear double stranded DNA. There are only three types of main structural proteins encoded in its genome.

Cell Structure, Metabolism and Life Cycle

Metabolism:

The virion integrates into the host cell's metabolism via passive diffusion in water. Pyrobaculum and Thermoproteus archaea are common host organisms. The virion is not responsible for encoding genome replication proteins, and is instead responsible for the recruitment of host cell machinery.

Ecology and Pathogenesis

Habitat; symbiosis; biogeochemical significance; contributions to environment.

If relevant, how does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.

References

Prangishvili , D. and Krupovic, M. (2018) ICTV. Edited by A.M. Kropinski and S.G. Siddell. Available at: https://ictv.global/report/chapter/globuloviridae/globuloviridae (Accessed: 20 November 2024).

Author

Page authored by Jordan Scott, Andrew Edwards, Jayde Walker, & Taylor Houston, students of Prof. Bradley Tolar at UNC Wilmington.