This topic is quite interesting and applicable to many topics in medicine today. Your introduction and conclusion are both very strong. In the introduction, though, I would maybe introduce the last sentence of the first paragraph before you talk about the glycylcycline-class of antibiotics (sentence 3)? I would also be interested in seeing a picture of the Bhattacharya (2009) class of antibiotics. The three papers you discuss are also quite strong. However, you talk about the structure and binding of tigecycline to the ribosome a lot in the first two topics. Could you tie the third topic into your first two a little more succinctly? How exactly does the structure and tight binding ability of tigecycline relate to the efflux pumps transcribed in tet-resistance bacteria? Overall, a neat topic with lots of implications! -Maggie
I enjoyed your discussion on glycylcycline antibiotics. You did a good job of picking topics to discuss about the antibiotics that appeal to a great deal of interests, both medical and research related. The first two topics flowed well, starting with the developmental and mechanistic details of the drug design and I think it was also good that you included information about the response of the microbial world. I also think you did a nice job of explaining technical details in a way that was easy for the reader to understand and your choice of figures further aided the clarity of your explanations.You mentioned that only one antibiotic of this class was in clinical use. Are there others that are currently in the development stages that bacteria may not yet have a resistance to? Also, is this antibiotic approved for use in all patients or are there restrictions on who it can be administered to? Overall, great job!