Candida Krusei

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1. Classification

a. Higher order taxa

Domain: Eukarya
Kingdom: Fungi
Phylum: Ascomycota
Class: Saccharomycetes
Order: Saccharomycetales
Family: Saccharomycetaceae
Genus: Candida
Species: Krusei
[1]

2. Description and significance

Candida krusei is a yeast species that does not produce spores that is usually found growing as a single cell or as pseudohyphae [1]. In the single cell form, the cells of C. krusei are round or ovoid and can be easily separated while in the pseudohyphae form the cells are more elongated and attached to neighboring cells [2]. C. krusei is considered a relatively uncommon, emerging opportunistic human pathogen [3] that infects mainly immunocompromised patients, especially those that have some form of leukemia or other deficiencies in white blood cells [4]. C. krusei is gaining recognition in the world today since it is a multidrug resistant pathogen due to its ability to rapidly adapt to antifungal treatments and its complex susceptibility profile [5]. C. krusei is most often found in the human microbiome in immunocompromised patients [4], in some foods, and it is used extensively in chocolate production from West African cocoa beans.

Before the 1960s, C. krusei was regarded as a species with low pathogenicity and virulence in humans compared to other species in the genus Candida [4]; however, since 1960, C. krusei infections have increased alarmingly. C. krusei is inherently resistant to the triazole antifungal, fluconazole which allows it to persist and cause infection in humans being treated with antifungals where other fungi cannot survive [6]. Of particular note is the high presence of C. krusei in the human microbiome in immunocompromised patients due to selection by prophylactic oral rinse therapy [2]. The increased use of fluconazole and other traizole antifungals to treat and quell fungal infections has thus led to a marked increase in infections by C. krusei , making it increasingly relevant in the world today [1]. However, although much is now known about C. krusei because of its status as an emerging pathogen, its genome has yet to be characterized and sequenced [7]. Additionally, a point of contention in the scientific community is whether or not C. krusei should be re-classified into a genus of its own since srRNA analysis and analysis of various ubiquinone systems in related species reveals C. krusei diverged much earlier than other Candida species [3].

3. Genome structure

Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence?

4. Cell structure

Interesting features of cell structure. Can be combined with “metabolic processes”

5. Metabolic processes

Describe important sources of energy, electrons, and carbon (i.e. trophy) for the organism/organisms you are focusing on, as well as important molecules it/they synthesize(s).

6. Ecology

Habitat; symbiosis; contributions to the environment.

7. Pathology

How does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.

7. Key microorganisms

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8. Current Research

Include information about how this microbe (or related microbes) are currently being studied and for what purpose

9. References

It is required that you add at least five primary research articles (in same format as the sample reference below) that corresponds to the info that you added to this page. [Sample reference] Faller, A., and Schleifer, K. "Modified Oxidase and Benzidine Tests for Separation of Staphylococci from Micrococci". Journal of Clinical Microbiology. 1981. Volume 13. p. 1031-1035.